Murine Broadly Reactive Antineuraminidase Monoclonal Antibodies Protect Mice from Recent Influenza B Virus Isolates and Partially Inhibit Virus Transmission in the Guinea Pig Model

• Published in: mSphere Vol. 7; no. 5; p. e0092721
• Main Authors: Tan, Jessica, Chromikova, Veronika, O'Dell, George, Sordillo, Emilia Mia, Simon, Viviana, van Bakel, Harm, Krammer, Florian, McMahon, Meagan
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 26.10.2022
• Subjects: Adaptation; Animals; Antibodies, Monoclonal - therapeutic use; Antibodies, Viral; Antigens; Antiviral Agents; Antiviral drugs; Clinical isolates; Coronaviruses; COVID-19; Cross-protection; Disease Models, Animal; Drug dosages; Drug resistance; Epitopes; Exo-a-sialidase; experimental therapeutics; FDA approval; Guinea Pigs; Humans; Infections; Influenza; Influenza B; Influenza B virus; Influenza Vaccines; Intranasal administration; Lungs; Mice; Monoclonal antibodies; Morbidity; Neuraminidase; Orthomyxoviridae Infections; Pandemics; Public health; Research Article; Vaccines; Virology; Virulence; Viruses; New York; United States > US; New York City New York; experimental therapeutics; Influenza; monoclonal antibodies

The global health burden of influenza B viruses, especially in children, has long been underappreciated. Although two antigenically distinct influenza B virus lineages cocirculated before the coronavirus disease 2019 (COVID-19) pandemic, the commonly used trivalent seasonal vaccines contain antigens...