Binding Mechanism of Neutralizing Nanobodies Targeting SARS-CoV‑2 Spike Glycoprotein

• Published in: Journal of chemical information and modeling Vol. 61; no. 10; pp. 5152 - 5160
• Main Authors: Golcuk, Mert, Hacisuleyman, Aysima, Erman, Burak, Yildiz, Ahmet, Gur, Mert
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.10.2021
• Subjects: Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Binding Sites; Computational Biochemistry; COVID-19; Glycoproteins; Humans; Molecular dynamics; Mutation; Protein Binding; Receptors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Single-Domain Antibodies - immunology; Spike Glycoprotein, Coronavirus - immunology; Viral diseases

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human cells upon binding of its spike (S) glycoproteins to ACE2 receptors. Several nanobodies neutralize SARS-CoV-2 infection by binding to the receptor-binding domain (RBD) of the S protein, but how their binding antagonizes S-ACE2...