Investigation of Human Exposure to Triclocarban after Showering and Preliminary Evaluation of Its Biological Effects

• Published in: Environmental science & technology Vol. 45; no. 7; pp. 3109 - 3115
• Main Authors: Schebb, Nils Helge, Inceoglu, Bora, Ahn, Ki Chang, Morisseau, Christophe, Gee, Shirley J, Hammock, Bruce D
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.04.2011
• Subjects: Animals; Anti-Infective Agents, Local - analysis; Anti-Infective Agents, Local - metabolism; Anti-Infective Agents, Local - toxicity; Antimicrobial agents; Applied sciences; Baths - statistics & numerical data; Biological and medical sciences; Carbanilides - analysis; Carbanilides - metabolism; Carbanilides - toxicity; Chemical compounds; Chromatography, Liquid; Domestic and cosmetic products toxicology; Ecotoxicology and Human Environmental Health; Environmental Exposure - analysis; Environmental Exposure - statistics & numerical data; Enzymes; Exact sciences and technology; Extraction processes; Human exposure; Humans; Male; Medical sciences; Metabolites; Pollution; Rats; Soap; Solid Phase Extraction; Studies; Tandem Mass Spectrometry; Toxicology; Urine; Water Pollutants, Chemical - analysis; Water Pollutants, Chemical - metabolism; Water Pollutants, Chemical - toxicity; Cosmetic; Human; Evaluation; Rat; Toxicity; Rodentia; Exposure; Soap; Triclocarban; Vertebrata; Mammalia; Health and environment; Chlorine Organic compounds; Animal; Antiseptic; Ureas; Biological effect; Public health

The antibacterial soap additive triclocarban (TCC) is widely used in personal care products. TCC has a high environmental persistence. We developed and validated a sensitive online solid-phase extraction−LC−MS/MS method to rapidly analyze TCC and its major metabolites in urine and other biological s...