Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

• Published in: mBio Vol. 12; no. 6; pp. e0255821 - 21
• Main Authors: Hammam, Elie, Sinha, Ameya, Baumgarten, Sebastian, Nardella, Flore, Liang, Jiaqi, Miled, Samia, Bonhomme, Frédéric, Erdmann, Diane, Arcangioli, Benoit, Arimondo, Paola B., Dedon, Peter, Preiser, Peter, Scherf, Artur
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 21.12.2021
• Subjects: Biochemistry, Molecular Biology; Cytosine - metabolism; DNA Methylation; DNMT2; Epigenome; epitranscriptomic; Genetics and Molecular Biology; homeostasis; Humans; Life Sciences; malaria; Malaria, Falciparum - parasitology; Methyltransferases - genetics; Methyltransferases - metabolism; Microbiology and Parasitology; Plasmodium falciparum - enzymology; Plasmodium falciparum - genetics; Plasmodium falciparum - physiology; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Research Article; RNA cytosine methylation; RNA Processing, Post-Transcriptional; RNA, Protozoan - genetics; RNA, Protozoan - metabolism; RNA, Transfer - genetics; RNA, Transfer - metabolism; Stress, Physiological; tRNA; homeostasis; DNMT2; epitranscriptomic; stress response; tRNA; tRNA modification; RNA cytosine methylation; tRNA cytosine methylation; malaria

P. falciparum is the most virulent malaria parasite species, accounting for the majority of the disease mortality and morbidity. Understanding how this pathogen is able to adapt to different cellular and environmental stressors during its complex life cycle is crucial in order to develop new strateg...