In vivo observation and biophysical interpretation of time-dependent diffusion in human cortical gray matter

• Published in: arXiv.org
• Main Authors: Hong-Hsi, Lee, Papaioannou, Antonios, Novikov, Dmitry S, Fieremans, Els
• Format: Paper Journal Article
• Language: English
• Published: Ithaca Cornell University Library, arXiv.org 04.08.2020
• Subjects: Computer simulation; Diffusion barriers; Diffusion length; Diffusivity; Effective medium theory; Exchanging; Kurtosis; Physics - Biological Physics; Physics - Medical Physics; Power law; Synapses; Time dependence

The dependence of the diffusion MRI signal on the diffusion time \(t\) is a hallmark of tissue microstructure at the scale of the diffusion length. Here we measure the time-dependence of the mean diffusivity \(D(t)\) and mean kurtosis \(K(t)\) in cortical gray matter and in 25 gray matter sub-region...