pH-Mediated Regulation of Polymer Transport Through SiN Pores
We characterize the pH controlled polymer capture and transport thorough silicon nitride (SiN) pores subject to protonation. A charge regulation model able to reproduce the experimental zeta potential of SiN pores is coupled with electrohydrodynamic polymer transport equations. The formalism can qua...
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| Published in | arXiv.org |
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| Main Authors | , |
| Format | Paper Journal Article |
| Language | English |
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10.09.2018
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| ISSN | 2331-8422 |
| DOI | 10.48550/arxiv.1806.03521 |
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| Abstract | We characterize the pH controlled polymer capture and transport thorough silicon nitride (SiN) pores subject to protonation. A charge regulation model able to reproduce the experimental zeta potential of SiN pores is coupled with electrohydrodynamic polymer transport equations. The formalism can quantitatively explain the experimentally observed non-monotonic pH dependence of avidin conductivity in terms of the interplay between the electroosmotic and electrophoretic drag forces on the protein. We also scrutinize the DNA conductivity of SiN pores. We show that in the low pH regime where the amphoteric pore is cationic, DNA-pore attraction acts as an electrostatic trap. This provides a favorable condition for fast polymer capture and extended translocation required for accurate polymer sequencing. |
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| AbstractList | Europhysics Letters 123, 38003 (2018) We characterize the pH controlled polymer capture and transport thorough
silicon nitride (SiN) pores subject to protonation. A charge regulation model
able to reproduce the experimental zeta potential of SiN pores is coupled with
electrohydrodynamic polymer transport equations. The formalism can
quantitatively explain the experimentally observed non-monotonic pH dependence
of avidin conductivity in terms of the interplay between the electroosmotic and
electrophoretic drag forces on the protein. We also scrutinize the DNA
conductivity of SiN pores. We show that in the low pH regime where the
amphoteric pore is cationic, DNA-pore attraction acts as an electrostatic trap.
This provides a favorable condition for fast polymer capture and extended
translocation required for accurate polymer sequencing. We characterize the pH controlled polymer capture and transport thorough silicon nitride (SiN) pores subject to protonation. A charge regulation model able to reproduce the experimental zeta potential of SiN pores is coupled with electrohydrodynamic polymer transport equations. The formalism can quantitatively explain the experimentally observed non-monotonic pH dependence of avidin conductivity in terms of the interplay between the electroosmotic and electrophoretic drag forces on the protein. We also scrutinize the DNA conductivity of SiN pores. We show that in the low pH regime where the amphoteric pore is cationic, DNA-pore attraction acts as an electrostatic trap. This provides a favorable condition for fast polymer capture and extended translocation required for accurate polymer sequencing. |
| Author | Ala-Nissila, Tapio Sahin Buyukdagli |
| Author_xml | – sequence: 1 fullname: Sahin Buyukdagli – sequence: 2 givenname: Tapio surname: Ala-Nissila fullname: Ala-Nissila, Tapio |
| BackLink | https://doi.org/10.48550/arXiv.1806.03521$$DView paper in arXiv https://doi.org/10.1209/0295-5075/123/38003$$DView published paper (Access to full text may be restricted) |
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| Copyright | 2018. This work is published under http://arxiv.org/licenses/nonexclusive-distrib/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://arxiv.org/licenses/nonexclusive-distrib/1.0 |
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| Snippet | We characterize the pH controlled polymer capture and transport thorough silicon nitride (SiN) pores subject to protonation. A charge regulation model able to... Europhysics Letters 123, 38003 (2018) We characterize the pH controlled polymer capture and transport thorough silicon nitride (SiN) pores subject to... |
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| SubjectTerms | Deoxyribonucleic acid Dependence DNA Drag Electrohydrodynamics Physics - Soft Condensed Matter Polymers Porosity Proteins Protonation Silicon nitride Transport equations Zeta potential |
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| Title | pH-Mediated Regulation of Polymer Transport Through SiN Pores |
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