Human colonic intraepithelial lymphocytes regulate the cytokines produced by lamina propria mononuclear cells

• Published in: Mediators of Inflammation Vol. 1997; no. 2; pp. 105 - 109
• Main Authors: Hoang, P, Dehennin, J P, Li, L, Sibille, C, Geubel, A, Vaerman, J P
• Format: Journal Article
• Language: English
• Published: United States Hindawi Limiteds 1997; Hindawi Publishing Corporation; Wiley
• Subjects: Intraepithelial lymphocytes; Interleukin-2; Interleukin-10; Interferon-γ

Using an in vitro autologous human system, the immunomodulatory function of colonic intraepithelial lymphocytes (IEL) on cytokine production by lamina propria mononuclear cells (LPMNC) has been investigated. In contrast to LPMNC, colonic IEL produced only low amounts of IL-10, interferon-γ and inter...