Small proteins can no longer be ignored

• Published in: Annual review of biochemistry Vol. 83; p. 753
• Main Authors: Storz, Gisela, Wolf, Yuri I, Ramamurthi, Kumaran S
• Format: Journal Article
• Language: English
• Published: United States 01.01.2014
• Subjects: Amino Acids - chemistry; Animals; Bacillus subtilis - metabolism; Bacterial Proteins - chemistry; Bacteriophages - metabolism; Cell Division; Codon; Computational Biology; Drosophila; Escherichia coli - metabolism; Open Reading Frames; Protein Kinases - metabolism; Proteins - chemistry; Ribosomes - chemistry; RNA - chemistry; Signal Transduction; cell division; membrane; transport; signal transduction; protein; sporulation

Small proteins, here defined as proteins of 50 amino acids or fewer in the absence of processing, have traditionally been overlooked due to challenges in their annotation and biochemical detection. In the past several years, however, increasing numbers of small proteins have been identified either t...