Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction

• Published in: Journal of virology Vol. 97; no. 2; p. e0165522
• Main Authors: Duran-Castells, Clara, Llano, Anuska, Kawana-Tachikawa, Ai, Prats, Anna, Martinez-Zalacain, Ignacio, Kobayashi-Ishihara, Mie, Oriol-Tordera, Bruna, Peña, Ruth, Gálvez, Cristina, Silva-Arrieta, Sandra, Clotet, Bonaventura, Riveira-Muñoz, Eva, Ballana, Esther, Prado, Julia G., Martinez-Picado, Javier, Sanchez, Jorge, Mothe, Beatriz, Hartigan-O’Connor, Dennis, Wyss-Coray, Tony, Meyerhans, Andreas, Gisslén, Magnus, Price, Richard W., Soriano-Mas, Carles, Muñoz-Moreno, José Antonio, Brander, Christian, Ruiz-Riol, Marta
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 28.02.2023
• Subjects: Biomarkers; Clinical Medicine; disorders (HAND); Genomics and Proteomics; HIV Infections - complications; HIV Infections - drug therapy; HIV reservoir; HIV-1; HIV-associated neurocognitive; Humans; Klinisk medicin; Nervous System Diseases - drug therapy; Nervous System Diseases - etiology; Nervous System Diseases - virology; Neurofilament Proteins - metabolism; neuroimaging; neurological disorder; plasma; proteomics; Proviruses - metabolism; Quality of Life; Sirtuin 2 - metabolism; Viral Load; virus infection control; Virus-Cell Interactions; HIV-1; plasma proteomics; HIV-associated neurocognitive disorders (HAND); virus infection control; HIV reservoir; neuroimaging; neurological disorder

Neurocognitive disorders are frequently reported in people living with HIV (PLWH) even with the introduction of combined antiretroviral treatment (cART). To identify biomarkers and potential therapeutic tools to target HIV infection in peripheral blood and in the central nervous system (CNS), plasma...