Apollo: A Sequencing-Technology-Independent, Scalable, and Accurate Assembly Polishing Algorithm

• Published in: arXiv.org
• Main Authors: Firtina, Can, Kim, Jeremie S, Alser, Mohammed, Cali, Damla Senol, Cicek, A Ercument, Alkan, Can, Mutlu, Onur
• Format: Paper Journal Article
• Language: English
• Published: Ithaca Cornell University Library, arXiv.org 07.03.2020
• Subjects: Algorithms; Alignment; Assemblies; Assembly; Computer Science - Computational Engineering, Finance, and Science; Computer Science - Learning; Dependence; Error analysis; Gene sequencing; Genomes; Markov chains; Polishes; Polishing; Quantitative Biology - Genomics; State of the art; Viterbi algorithm detectors

Long reads produced by third-generation sequencing technologies are used to construct an assembly (i.e., the subject's genome), which is further used in downstream genome analysis. Unfortunately, long reads have high sequencing error rates and a large proportion of bps in these long reads are i...