Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2‑Phenylpyridine Ligands

• Published in: Organometallics Vol. 34; no. 11; pp. 2683 - 2694
• Main Authors: Millett, Adam J, Habtemariam, Abraha, Romero-Canelón, Isolda, Clarkson, Guy J, Sadler, Peter J
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 08.06.2015; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Inorganic & Nuclear; Chemistry, Organic; Physical Sciences; Science & Technology; LOCALIZATION; MOLECULAR CALCULATIONS; RHODIUM; DNA; REACTIVITY; DINUCLEAR; RUTHENIUM; IR; WATER EXCHANGE; CELLULAR ACCUMULATION

We report the synthesis, characterization, and antiproliferative activity of 15 iridium­(III) half-sandwich complexes of the type [(η5-Cp*)­Ir­(2-(R′-phenyl)-R-pyridine)­Cl] bearing either an electron-donating (−OH, −CH2OH, −CH3) or electron-withdrawing (−F, −CHO, −NO2) group at various positions on...