Two Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Studies To Investigate the Safety, Tolerability, and Pharmacokinetics of an Anti-Influenza A Virus Monoclonal Antibody, MHAA4549A, in Healthy Volunteers - Lim, Jeremy J.; Deng, Rong; Derby, Michael A.; Larouche, Richard; Horn, Priscilla; Anderson, Malia; Maia, Mauricio; Carrier, Stephanie; Pelletier, Isabelle; Burgess, Tracy; Kulkarni, Priya; Newton, Elizabeth; et al. (Antimicrobial agents and chemotherapy, 2016)
Keywords: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal - adverse effects; Antibodies, Monoclonal - pharmacokinetics; Antiviral Agents; Antiviral Agents - adverse effects; Antiviral Agents - pharmacokinetics; Drug Administration Schedule; Female; Gene Expression; Half-Life; Headache - diagnosis; Headache - etiology; Healthy Volunteers; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; Humans; Influenza A virus; Influenza, Human - drug therapy; Influenza, Human - virology; Injections, Intravenous; Male; Middle Aged; Patient Safety