Kibdelomycin Is a Bactericidal Broad-Spectrum Aerobic Antibacterial Agent

• Published in: Antimicrobial agents and chemotherapy Vol. 59; no. 6; pp. 3474 - 3481
• Main Authors: Singh, Sheo B., Dayananth, Priya, Balibar, Carl J., Garlisi, Charles G., Lu, Jun, Kishii, Ryuta, Takei, Masaya, Fukuda, Yasumichi, Ha, Sookhee, Young, Katherine
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.06.2015
• Subjects: Acinetobacter baumannii; Acinetobacter baumannii - drug effects; Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; Clostridium difficile; Escherichia coli; Escherichia coli - drug effects; Experimental Therapeutics; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pyrroles; Pyrroles - pharmacology; Pyrrolidinones; Pyrrolidinones - pharmacology; Staphylococcus aureus; Staphylococcus aureus - drug effects; Streptococcus pneumoniae
• ISSN: 0066-4804; 1098-6596; 1098-6596
• DOI: 10.1128/AAC.00382-15

Bacterial resistance to antibiotics continues to grow and pose serious challenges, while the discovery rate for new antibiotics declines. Kibdelomycin is a recently discovered natural-product antibiotic that inhibits bacterial growth by inhibiting the bacterial DNA replication enzymes DNA gyrase and...