Peptide Tethering: Pocket-Directed Fragment Screening for Peptidomimetic Inhibitor Discovery - Modell, Ashley E; Marrone, Frank; Panigrahi, Nihar R; Zhang, Yingkai; Arora, Paramjit S (Journal of the American Chemical Society, 2022)
Keywords: Chemistry; Chemistry, Multidisciplinary; Drug Discovery; Humans; Ligands; Models, Molecular; p300-CBP Transcription Factors - antagonists & inhibitors; p300-CBP Transcription Factors - chemistry; p300-CBP Transcription Factors - metabolism; peptides; Peptides - chemistry; Peptides - pharmacology; Peptidomimetics - chemistry; Peptidomimetics - pharmacology; Physical Sciences; Science & Technology; topography; CBP; TRANSCRIPTION FACTOR-BINDING; LINEAGE LEUKEMIA PROTEIN; HIGH-AFFINITY LIGANDS; STRUCTURAL BASIS; MOLECULAR RECOGNITION; KIX DOMAIN; ALLOSTERIC SITE; HELICAL PROTEIN INTERFACES; SURFACES