Photostable Ratiometric Pdot Probe for in Vitro and in Vivo Imaging of Hypochlorous Acid

• Published in: Journal of the American Chemical Society Vol. 139; no. 20; pp. 6911 - 6918
• Main Authors: Wu, Li, Wu, I-Che, DuFort, Christopher C, Carlson, Markus A, Wu, Xu, Chen, Lei, Kuo, Chun-Ting, Qin, Yuling, Yu, Jiangbo, Hingorani, Sunil R, Chiu, Daniel T
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.05.2017
• Subjects: fluorescence; fluorescent dyes; Fluorescent Dyes - chemistry; Hypochlorous Acid - analysis; image analysis; macrophages; mice; Molecular Structure; peritonitis; photobleaching; Photochemical Processes; photostability; polymers; reactive oxygen species

Developing probes for the detection of reactive oxygen species (ROS), a hallmark of many pathophysiological process, is imperative to both understanding the precise roles of ROS in many life-threatening diseases and optimizing therapeutic interventions. We herein report an all-in-one fluorescent sem...