CATERPILLER: a novel gene family important in immunity, cell death, and diseases

• Published in: Annual review of immunology Vol. 23; no. 1; pp. 387 - 414
• Main Authors: Ting, Jenny P-Y, Davis, Beckley K
• Format: Journal Article
• Language: English
• Published: United States Annual Reviews, Inc 01.01.2005
• Subjects: Animals; Cell death; Cell Death - genetics; Disease; Evolution, Molecular; Genes, Plant; Humans; Immunity, Innate - genetics; Mammals - genetics; Mammals - immunology; Multigene Family; Mutation; Plant Diseases - genetics

The newly discovered CATERPILLER (CLR) gene family encodes proteins with a variable but limited number of N-terminal domains, followed by a nucleotide-binding domain (NBD) and leucine-rich repeats (LRR). The N-terminal domain consists of transactivation, CARD, Pyrin, or BIR domains, with a minority...