Prevalence of Incompletely Penetrant Huntington's Disease Alleles Among Individuals With Major Depressive Disorder

• Published in: American Journal of Psychiatry Vol. 167; no. 5; pp. 574 - 579
• Main Authors: Perlis, Roy H, Smoller, Jordan W, Mysore, Jayalakshmi, Sun, Mei, Gillis, Tammy, Purcell, Shaun, Rietschel, Marcella, Nöthen, Markus M, Witt, Stephanie, Maier, Wolfgang, Iosifescu, Dan V, Sullivan, Patrick, Rush, A. John, Fava, Maurizio, Breiter, Hans, Macdonald, Marcy, Gusella, James
• Format: Journal Article
• Language: English
• Published: Arlington, VA American Psychiatric Association 01.05.2010
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Alleles; Biological and medical sciences; Case-Control Studies; Chromosomes; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Deoxyribonucleic acid; Depression; Depressive Disorder, Major - genetics; DNA; Female; Hospitals; Human subjects; Humans; Huntington Disease - genetics; Huntingtons disease; Illnesses; Male; Medical imaging; Medical sciences; Middle Aged; Mood disorders; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Organic mental disorders. Neuropsychology; Polymerase Chain Reaction; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Repetitive Sequences, Nucleic Acid - genetics; Studies; Womens health; Young Adult; Mood disorder; Nervous system diseases; Prevalence; Central nervous system disease; Huntington disease; Depression; Degenerative disease; Epidemiology; Public health; Genetic disease; Cerebral disorder; Extrapyramidal syndrome

ObjectivePresymptomatic individuals with the Huntingtin (HTT) CAG expansion mutation that causes Huntington's disease may have higher levels of depressive symptoms than healthy comparison populations. However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major de...