Discovery and Assembly-Line Biosynthesis of the Lymphostin Pyrroloquinoline Alkaloid Family of mTOR Inhibitors in Salinispora Bacteria

• Published in: Journal of the American Chemical Society Vol. 133; no. 34; pp. 13311 - 13313
• Main Authors: Miyanaga, Akimasa, Janso, Jeffrey E, McDonald, Leonard, He, Min, Liu, Hongbo, Barbieri, Laurel, Eustáquio, Alessandra S, Fielding, Elisha N, Carter, Guy T, Jensen, Paul R, Feng, Xidong, Leighton, Margaret, Koehn, Frank E, Moore, Bradley S
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 31.08.2011; Amer Chemical Soc
• Subjects: Actinomycetales - chemistry; Actinomycetales - metabolism; Alkaloids - chemistry; Alkaloids - metabolism; Alkaloids - pharmacology; Chemistry; Chemistry, Multidisciplinary; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - metabolism; Enzyme Inhibitors - pharmacology; Physical Sciences; Pyrroles - chemistry; Pyrroles - metabolism; Pyrroles - pharmacology; Quinolines - chemistry; Quinolines - metabolism; Quinolines - pharmacology; Science & Technology; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - metabolism; AMMOSAMIDES; STREPTOMYCES SP KY11783; IMMUNOSUPPRESSANT; LK6-A; SPONGE ZYZZYA-FULIGINOSA; FRUITING BODIES

The pyrroloquinoline alkaloid family of natural products, which includes the immunosuppressant lymphostin, has long been postulated to arise from tryptophan. We now report the molecular basis of lymphostin biosynthesis in three marine Salinispora species that maintain conserved biosynthetic gene clu...