Serum Urate as a Predictor of Clinical and Radiographic Progression in Parkinson Disease

• Published in: Archives of neurology (Chicago) Vol. 65; no. 6; pp. 716 - 723
• Main Authors: Schwarzschild, Michael A, Schwid, Steven R, Marek, Kenneth, Watts, Arthur, Lang, Anthony E, Oakes, David, Shoulson, Ira, Ascherio, Alberto
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 01.06.2008
• Subjects: Antioxidants; Biomarkers - blood; Cohort Studies; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Medical prognosis; Medical research; Middle Aged; Neurology; Parkinson Disease - blood; Parkinson Disease - diagnosis; Parkinson Disease - diagnostic imaging; Parkinson's disease; Predictive Value of Tests; Prospective Studies; Radiography; Uric Acid - blood

OBJECTIVE To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD. DESIGN Prospective study. SETTING The Parkinson Research Examination of CEP-1347 Trial (PRECEPT) study,...