Failure of Anterior Cingulate Activation and Connectivity With the Amygdala During Implicit Regulation of Emotional Processing in Generalized Anxiety Disorder

• Published in: The American journal of psychiatry Vol. 167; no. 5; pp. 545 - 554
• Main Authors: Etkin, Amit, Prater, Katherine E., Hoeft, Fumiko, Menon, Vinod, Schatzberg, Alan F.
• Format: Journal Article
• Language: English
• Published: Arlington, VA American Psychiatric Association 01.05.2010
• Subjects: Adaptation, Psychological - physiology; Adult; Adult and adolescent clinical studies; Amygdala - physiopathology; Anxiety; Anxiety Disorders - physiopathology; Anxiety disorders. Neuroses; Biological and medical sciences; Case-Control Studies; Conflict (Psychology); Emotions - physiology; Female; Gyrus Cinguli - physiopathology; Humans; Magnetic Resonance Imaging; Male; Medical sciences; Miscellaneous; Neural Pathways - physiopathology; Neurosciences; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology; Psychopathology. Psychiatry; Studies; Affect affectivity; Amygdala; Central nervous system; Anxiety disorder; Cognition; Basal ganglion; Activation; Emotion emotionality; Encephalon; Cingulate cortex; Generalized anxiety disorder; Information processing; Amygdaloid nucleus; Failure

ObjectiveClinical data suggest that abnormalities in the regulation of emotional processing contribute to the pathophysiology of generalized anxiety disorder, yet these abnormalities remain poorly understood at the neurobiological level. The authors recently reported that in healthy volunteers the p...