Age of Methylphenidate Treatment Initiation in Children With ADHD and Later Substance Abuse: Prospective Follow-Up Into Adulthood

• Published in: The American journal of psychiatry Vol. 165; no. 5; pp. 604 - 609
• Main Authors: Mannuzza, Salvatore, Klein, Rachel G., Truong, Nhan L., Moulton, John L., Roizen, Erica R., Howell, Kathryn H., Castellanos, Francisco X.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Association 01.05.2008
• Subjects: Addictive behaviors; Adolescent; Adult; Adult and adolescent clinical studies; Age Factors; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - epidemiology; Attention deficit hyperactivity disorder; Behavior; Biological and medical sciences; Central Nervous System Stimulants - therapeutic use; Child; Children & youth; Drug abuse; Drug therapy; Follow-Up Studies; Humans; Hyperactivity; Incidence; Male; Medical sciences; Methylphenidate - therapeutic use; Miscellaneous; Neuropharmacology; Observer Variation; Parents; Parents & parenting; Pharmacology. Drug treatments; Prevalence; Prospective Studies; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Substance-Related Disorders - epidemiology; Surveys and Questionnaires; United States; North America; America; Human; Social environment; CNS stimulant; Psychotropic; Mental health; Pharmacotherapy; Male; Substance abuse; Treatment; School age; Follow up study; Piperidine derivatives; Adolescent; Young adult; Risk factor; Attention disorder with hyperactivity; Child; Age; Methylphenidate; Public health

Objective: Animal studies have shown that age at stimulant exposure is positively related to later drug sensitivity. The purpose of this study was to examine whether age at initiation of stimulant treatment in children with attention deficit hyperactivity disorder (ADHD) is related to the subsequent...