Cross-Linking and Degradation of Step-Growth Hydrogels Formed by Thiol–Ene Photoclick Chemistry

• Published in: Biomacromolecules Vol. 13; no. 7; pp. 2003 - 2012
• Main Authors: Shih, Han, Lin, Chien-Chi
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 09.07.2012
• Subjects: Algorithms; Applied sciences; Chymotrypsin - chemistry; Click Chemistry; Cross-Linking Reagents - chemistry; crosslinking; Crosslinking and degradation; Dithiothreitol - chemistry; Exact sciences and technology; gelation; hydrogels; Hydrogels - chemical synthesis; Hydrogels - chemistry; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Models, Chemical; Molecular Weight; Norbornanes - chemistry; Oligopeptides - chemistry; Photochemical Processes; Physicochemistry of polymers; polyethylene glycol; Polyethylene Glycols - chemistry; Polymerization; Polymers and radiations; Proteolysis; Sulfhydryl Compounds - chemistry; tissue engineering; Biological properties; Viscoelasticity; Norbornene derivative copolymer; Peptides; Biodegradability; Property processing relationship; Ethylene oxide polymer; Colloidal gel; pH; Star polymer; Rate constant; Serine endopeptidases; Swelling; Enzyme; Ethylene oxide copolymer; Experimental study; Sulfur copolymer; In vitro; Functional polymer; Chemical reaction kinetics; Hydrolysis; Peptidases; Chymotrypsin; Alcohol copolymer; Ester copolymer; Mercaptoalcohol; Preparation; Enzymatic digestion; Hydrolases

Thiol–ene photoclick hydrogels have been used for a variety of tissue engineering and controlled release applications. In this step-growth photopolymerization scheme, four-arm poly(ethylene glycol) norbornene (PEG4NB) was cross-linked with dithiol containing cross-linkers to form chemically cross-li...