Hierarchical Self-Assembly Pathways of Peptoid Helices and Sheets

• Published in: Biomacromolecules Vol. 23; no. 3; pp. 992 - 1008
• Main Authors: Zhao, Mingfei, Lachowski, Kacper J, Zhang, Shuai, Alamdari, Sarah, Sampath, Janani, Mu, Peng, Mundy, Christopher J, Pfaendtner, Jim, De Yoreo, James J, Chen, Chun-Long, Pozzo, Lilo D, Ferguson, Andrew L
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14.03.2022
• Subjects: atomic force microscopy; BASIC BIOLOGICAL SCIENCES; catalytic activity; circular dichroism spectroscopy; Free energy; hydrophobicity; Microscopy, Atomic Force; Mixtures; molecular dynamics; Monomers; N-substituted Glycines; Nanostructures - chemistry; peptidomics; Peptoids - chemistry; Polymers; small-angle X-ray scattering; Solvents; thermodynamics; Two dimensional materials; X-Ray Diffraction
• ISSN: 1525-7797; 1526-4602; 1526-4602
• DOI: 10.1021/acs.biomac.1c01385

Peptoids (N-substituted glycines) are a class of tailorable synthetic peptidomic polymers. Amphiphilic diblock peptoids have been engineered to assemble 2D crystalline lattices with applications in catalysis and molecular separations. Assembly is induced in an organic solvent/water mixture by evapor...