Small-Molecule Inhibitors of the Coronavirus Spike: ACE2 Protein–Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV‑2

• Published in: ACS infectious diseases Vol. 7; no. 6; pp. 1519 - 1534
• Main Authors: Bojadzic, Damir, Alcazar, Oscar, Chen, Jinshui, Chuang, Sung-Ting, Condor Capcha, Jose M, Shehadeh, Lina A, Buchwald, Peter
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.06.2021
• Subjects: Angiotensin-Converting Enzyme 2 - metabolism; COVID-19 - prevention & control; Humans; Pandemics; Protein Interaction Domains and Motifs; SARS-CoV-2 - drug effects; Spike Glycoprotein, Coronavirus - antagonists & inhibitors; Virus Attachment - drug effects; ACE2; coronavirus; SARS-CoV-2; protein−protein interaction; antiviral; spike protein

Inhibitors of the protein–protein interaction (PPI) between the SARS-CoV-2 spike protein and human ACE2 (hACE2), which acts as a ligand–receptor pair that initiates the viral attachment and cellular entry of this coronavirus causing the ongoing COVID-19 pandemic, are of considerable interest as pote...