Unraveling Molecular Interactions in Liquid–Liquid Phase Separation of Disordered Proteins by Atomistic Simulations

• Published in: The journal of physical chemistry. B Vol. 124; no. 41; pp. 9009 - 9016
• Main Authors: Paloni, Matteo, Bailly, Rémy, Ciandrini, Luca, Barducci, Alessandro
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.10.2020
• Subjects: Amino Acid Sequence; arginine; B: Biophysics; Physical Chemistry of Biological Systems and Biomolecules; Chemical Sciences; DEAD-box RNA helicases; Intrinsically Disordered Proteins; mutagenesis; or physical chemistry; Organelles; Phase Transition; RNA; separation; Theoretical and

Membraneless organelles are dynamical cellular condensates formed via biomolecular liquid–liquid phase separation of proteins and RNA molecules. Multiple evidence suggests that in several cases disordered proteins are structural scaffolds that drive the condensation by forming a dynamic network of i...