A Complete Pipeline for Untargeted Urinary Volatolomic Profiling with Sorptive Extraction and Dual Polar and Nonpolar Column Methodologies Coupled with Gas Chromatography Time-of-Flight Mass Spectrometry

• Published in: Analytical chemistry (Washington) Vol. 95; no. 2; pp. 758 - 765
• Main Authors: Wen, Qing, Myridakis, Antonis, Boshier, Piers R., Zuffa, Simone, Belluomo, Ilaria, Parker, Aaron G., Chin, Sung-Tong, Hakim, Stephanie, Markar, Sheraz R., Hanna, George B.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.01.2023
• Subjects: Adenocarcinoma; analytical chemistry; Biomarkers; Chemistry; Chromatography; Gas chromatography; gas chromatography-mass spectrometry; Gas Chromatography-Mass Spectrometry - methods; Hexanal; human diseases; Humans; Ions; Mass Spectrometry; Mass spectroscopy; Organic compounds; p-Cymene; Pancreatic cancer; Pentanone; Pipelines; Quality control; Sample preparation; Scientific imaging; Spectroscopy; VOCs; Volatile organic compounds; Volatile Organic Compounds - analysis

Volatolomics offers an opportunity for noninvasive detection and monitoring of human disease. While gas chromatography–mass spectrometry (GC–MS) remains the technique of choice for analyzing volatile organic compounds (VOCs), barriers to wider adoption in clinical practice still exist, including: sa...