Near-Infrared Dual-Emission Quantum Dots–Gold Nanoclusters Nanohybrid via Co-Template Synthesis for Ratiometric Fluorescent Detection and Bioimaging of Ascorbic Acid In Vitro and In Vivo

• Published in: Analytical chemistry (Washington) Vol. 87; no. 19; pp. 9998 - 10005
• Main Authors: Zhao, Peng, He, Kaiyu, Han, Yitao, Zhang, Zhen, Yu, Mengze, Wang, Honghui, Huang, Yan, Nie, Zhou, Yao, Shouzhuo
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.10.2015
• Subjects: Analytical chemistry; Animals; ascorbic acid; Ascorbic Acid - analysis; Biomedical materials; Chemical synthesis; detection limit; Emissions; Environmental factors; Fluorescence; Fluorescent Dyes - chemistry; Gold; Gold - chemistry; HeLa Cells; Humans; image analysis; Imaging; In vitro testing; Lead - chemistry; Limit of Detection; Medical imaging; Metal Nanoparticles - chemistry; Metal Nanoparticles - ultrastructure; Mice; Mice, Nude; nanogold; Nanoparticles; Nanostructure; Optical Imaging; photostability; Quantum dots; Quantum Dots - chemistry; Quantum Dots - ultrastructure; Sulfides - chemistry; Surgical implants

Near-infrared (NIR) quantum dots (QDs) have emerged as an attractive bioimaging toolkit for exploring biological events because they can provide deep imaging penetration and low fluorescence background. However, the quantitation process of such NIR QDs generally relies on single-emission intensity c...