Electrochemical Biosensing Platform Using Hydrogel Prepared from Ferrocene Modified Amino Acid as Highly Efficient Immobilization Matrix

• Published in: Analytical chemistry (Washington) Vol. 86; no. 2; pp. 973 - 976
• Main Authors: Qu, Fengli, Zhang, Yi, Rasooly, Avraham, Yang, Minghui
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.01.2014
• Subjects: Amino acids; bioactive properties; Biochemistry; Biocompatibility; biocomposites; Biosensing Techniques - methods; Biosensors; blood glucose; Blood Glucose - analysis; blood sampling; Displays; Electrochemical Techniques; Electrochemistry; Electrodes; electron transfer; Electron Transport; Enzymes; Enzymes, Immobilized; Equipment Design; Fabrication; Ferrocenes; Ferrous Compounds - chemistry; Glucose; glucose oxidase; Glucose Oxidase - chemistry; hospitals; Humans; hydrocolloids; Hydrogels; Metallocenes; Microscopy, Electron, Scanning; nanofibers; Nanofibers - chemistry; Nanofibers - ultrastructure; phenylalanine; Phenylalanine - chemistry; Scanning electron microscopy

To increase the loading of glucose oxidase (GOx) and simplify glucose biosensor fabrication, hydrogel prepared from ferrocene (Fc) modified amino acid phenylalanine (Phe, F) was utilized for the incorporation of GOx. The synthesized hydrogel displays good biocompatibility and contains a significant...