Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer

• Published in: ACS chemical biology Vol. 12; no. 4; pp. 1001 - 1010
• Main Authors: Wong, Pamela T, Roberts, Edward W, Tang, Shengzhuang, Mukherjee, Jhindan, Cannon, Jayme, Nip, Alyssa J, Corbin, Kaitlin, Krummel, Matthew F, Choi, Seok Ki
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.04.2017
• Subjects: Animals; Cells, Cultured; Chromatography, Liquid - methods; Coumarins - chemistry; Kinetics; Mice; Photochemistry; Selective Estrogen Receptor Modulators - chemistry; Spectrum Analysis - methods; Tamoxifen - analogs & derivatives; Tamoxifen - chemistry

The use of coumarin caged molecules has been well documented in numerous photocaging applications including for the spatiotemporal control of Cre-estrogen receptor (Cre-ERT2) recombinase activity. In this article, we report that 4-hydroxytamoxifen (4OHT) caged with coumarin via a conventional ether...