Near-Infrared Light Responsive Nanoreactor for Simultaneous Tumor Photothermal Therapy and Carbon Monoxide-Mediated Anti-Inflammation
Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT may lead to adverse reactions including tumor recurrence and therapeutic resistance, which are regarded as major problems for PTT. Here, a near...
Saved in:
| Published in | ACS central science Vol. 6; no. 4; pp. 555 - 565 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
22.04.2020
|
| Online Access | Get full text |
Cover
Loading…
| Abstract | Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT may lead to adverse reactions including tumor recurrence and therapeutic resistance, which are regarded as major problems for PTT. Here, a near-infrared (NIR) light-responsive nanoreactor (P@DW/BC) is fabricated to simultaneously realize tumor PTT and carbon monoxide (CO)-mediated anti-inflammatory therapy. Defective tungsten oxide (WO3) nanosheets (DW NSs) are decorated with bicarbonate (BC) via ferric ion-mediated coordination and then modified with polyethylene glycol (PEG) on the surface to fabricate PEG@DW/BC or P@DW/BC nanosheets. Upon 808 nm NIR laser irradiation, the DW content in P@DW/BC can serve as not only a photothermal agent to realize photothermal conversion but also a photocatalyst to convert carbon dioxide (CO2) to CO. In particular, the generated heat can also trigger the decomposition of BC to produce CO2 near the NSs, thus enhancing the photocatalytic CO generation. Benefiting from the efficient hyperthermia and CO generation under single NIR laser irradiation, P@DW/BC can realize effective thermal ablation of tumor and simultaneous inhibition of PTT-induced inflammation. |
|---|---|
| AbstractList | Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT may lead to adverse reactions including tumor recurrence and therapeutic resistance, which are regarded as major problems for PTT. Here, a near-infrared (NIR) light-responsive nanoreactor (P@DW/BC) is fabricated to simultaneously realize tumor PTT and carbon monoxide (CO)-mediated anti-inflammatory therapy. Defective tungsten oxide (WO
) nanosheets (DW NSs) are decorated with bicarbonate (BC) via ferric ion-mediated coordination and then modified with polyethylene glycol (PEG) on the surface to fabricate PEG@DW/BC or P@DW/BC nanosheets. Upon 808 nm NIR laser irradiation, the DW content in P@DW/BC can serve as not only a photothermal agent to realize photothermal conversion but also a photocatalyst to convert carbon dioxide (CO
) to CO. In particular, the generated heat can also trigger the decomposition of BC to produce CO
near the NSs, thus enhancing the photocatalytic CO generation. Benefiting from the efficient hyperthermia and CO generation under single NIR laser irradiation, P@DW/BC can realize effective thermal ablation of tumor and simultaneous inhibition of PTT-induced inflammation. Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT may lead to adverse reactions including tumor recurrence and therapeutic resistance, which are regarded as major problems for PTT. Here, a near-infrared (NIR) light-responsive nanoreactor (P@DW/BC) is fabricated to simultaneously realize tumor PTT and carbon monoxide (CO)-mediated anti-inflammatory therapy. Defective tungsten oxide (WO 3 ) nanosheets (DW NSs) are decorated with bicarbonate (BC) via ferric ion-mediated coordination and then modified with polyethylene glycol (PEG) on the surface to fabricate PEG@DW/BC or P@DW/BC nanosheets. Upon 808 nm NIR laser irradiation, the DW content in P@DW/BC can serve as not only a photothermal agent to realize photothermal conversion but also a photocatalyst to convert carbon dioxide (CO 2 ) to CO. In particular, the generated heat can also trigger the decomposition of BC to produce CO 2 near the NSs, thus enhancing the photocatalytic CO generation. Benefiting from the efficient hyperthermia and CO generation under single NIR laser irradiation, P@DW/BC can realize effective thermal ablation of tumor and simultaneous inhibition of PTT-induced inflammation. A near-infrared light-responsive nanoreactor with photothermal conversion and carbon monoxide (CO) production was fabricated for tumor photothermal therapy and CO-mediated anti-inflammation. Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT may lead to adverse reactions including tumor recurrence and therapeutic resistance, which are regarded as major problems for PTT. Here, a near-infrared (NIR) light-responsive nanoreactor (P@DW/BC) is fabricated to simultaneously realize tumor PTT and carbon monoxide (CO)-mediated anti-inflammatory therapy. Defective tungsten oxide (WO3) nanosheets (DW NSs) are decorated with bicarbonate (BC) via ferric ion-mediated coordination and then modified with polyethylene glycol (PEG) on the surface to fabricate PEG@DW/BC or P@DW/BC nanosheets. Upon 808 nm NIR laser irradiation, the DW content in P@DW/BC can serve as not only a photothermal agent to realize photothermal conversion but also a photocatalyst to convert carbon dioxide (CO2) to CO. In particular, the generated heat can also trigger the decomposition of BC to produce CO2 near the NSs, thus enhancing the photocatalytic CO generation. Benefiting from the efficient hyperthermia and CO generation under single NIR laser irradiation, P@DW/BC can realize effective thermal ablation of tumor and simultaneous inhibition of PTT-induced inflammation. Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT may lead to adverse reactions including tumor recurrence and therapeutic resistance, which are regarded as major problems for PTT. Here, a near-infrared (NIR) light-responsive nanoreactor (P@DW/BC) is fabricated to simultaneously realize tumor PTT and carbon monoxide (CO)-mediated anti-inflammatory therapy. Defective tungsten oxide (WO3) nanosheets (DW NSs) are decorated with bicarbonate (BC) via ferric ion-mediated coordination and then modified with polyethylene glycol (PEG) on the surface to fabricate PEG@DW/BC or P@DW/BC nanosheets. Upon 808 nm NIR laser irradiation, the DW content in P@DW/BC can serve as not only a photothermal agent to realize photothermal conversion but also a photocatalyst to convert carbon dioxide (CO2) to CO. In particular, the generated heat can also trigger the decomposition of BC to produce CO2 near the NSs, thus enhancing the photocatalytic CO generation. Benefiting from the efficient hyperthermia and CO generation under single NIR laser irradiation, P@DW/BC can realize effective thermal ablation of tumor and simultaneous inhibition of PTT-induced inflammation.Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT may lead to adverse reactions including tumor recurrence and therapeutic resistance, which are regarded as major problems for PTT. Here, a near-infrared (NIR) light-responsive nanoreactor (P@DW/BC) is fabricated to simultaneously realize tumor PTT and carbon monoxide (CO)-mediated anti-inflammatory therapy. Defective tungsten oxide (WO3) nanosheets (DW NSs) are decorated with bicarbonate (BC) via ferric ion-mediated coordination and then modified with polyethylene glycol (PEG) on the surface to fabricate PEG@DW/BC or P@DW/BC nanosheets. Upon 808 nm NIR laser irradiation, the DW content in P@DW/BC can serve as not only a photothermal agent to realize photothermal conversion but also a photocatalyst to convert carbon dioxide (CO2) to CO. In particular, the generated heat can also trigger the decomposition of BC to produce CO2 near the NSs, thus enhancing the photocatalytic CO generation. Benefiting from the efficient hyperthermia and CO generation under single NIR laser irradiation, P@DW/BC can realize effective thermal ablation of tumor and simultaneous inhibition of PTT-induced inflammation. |
| Author | Wang, Shi-Bo Ye, Jing-Jie Zou, Mei-Zhen Zhang, Cheng Liu, Chuan-Jun Zhang, Xian-Zheng |
| AuthorAffiliation | Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry Institute for Advanced Studies (IAS) |
| AuthorAffiliation_xml | – name: Institute for Advanced Studies (IAS) – name: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry |
| Author_xml | – sequence: 1 givenname: Shi-Bo surname: Wang fullname: Wang, Shi-Bo organization: Institute for Advanced Studies (IAS) – sequence: 2 givenname: Cheng surname: Zhang fullname: Zhang, Cheng organization: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry – sequence: 3 givenname: Jing-Jie surname: Ye fullname: Ye, Jing-Jie organization: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry – sequence: 4 givenname: Mei-Zhen surname: Zou fullname: Zou, Mei-Zhen organization: Institute for Advanced Studies (IAS) – sequence: 5 givenname: Chuan-Jun orcidid: 0000-0001-9543-7763 surname: Liu fullname: Liu, Chuan-Jun organization: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry – sequence: 6 givenname: Xian-Zheng orcidid: 0000-0001-6242-6005 surname: Zhang fullname: Zhang, Xian-Zheng email: xz-zhang@whu.edu.cn organization: Institute for Advanced Studies (IAS) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32342005$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UstuEzEUHaEiWkp_gAWaJZsJfo7HG6Qq4hEpLQjC2rrj8SSOZuxgeyr6Afw3TpMWyqKSLVv3nod0z31ZnDjvTFG8xmiGEcHvQEdtXIrazmSLMGXkWXFGqGCVkByfPPwZPS0uYtwihDCra07Ei-KUkoxHiJ8Vv68NhGrh-gDBdOXSrjep_Gbizrtob0x5Dc4HAzr5UPb5frfjNCRwxk-xXE1jLn3d-OTTxoQRhnKVX9jdluC6cg6h9a688s7_sp2prkxnIWWXS5fs3nOAcYRkvXtVPO9hiObi-J4XPz5-WM0_V8svnxbzy2UFHIlUCSONFNCRrhcNY5TnY5jAPa-NlD1Q0iDoQDZaQ1_TRsqmFZJ2QHAvuGnpebE46HYetmoX7AjhVnmw6q7gw1pBSFYPRnEh2rbuwQCnDGsimaZty3tWU9RghrLW-4PWbmpH0-3DCDA8En3ccXaj1v5GCdxgikUWeHsUCP7nZGJSo82ZDsNhuopQyWvKKMEZ-uZfrweT-xwzoDkAdPAxBtMrbdPdaLO1HRRGar816u_WqOPWZCr5j3qv_iRpdiDlntr6Kbgc21OEP1uV280 |
| CitedBy_id | crossref_primary_10_1039_D2BM01823C crossref_primary_10_1002_advs_202403795 crossref_primary_10_1016_j_bioactmat_2021_04_030 crossref_primary_10_1021_acs_nanolett_4c01582 crossref_primary_10_1016_j_actbio_2022_09_019 crossref_primary_10_1002_wnan_1744 crossref_primary_10_1016_j_ccr_2024_216430 crossref_primary_10_1038_s41467_024_48319_9 crossref_primary_10_1016_j_ccr_2022_214897 crossref_primary_10_1016_j_biomaterials_2021_120790 crossref_primary_10_1016_j_biomaterials_2021_121120 crossref_primary_10_1016_j_cej_2022_137321 crossref_primary_10_1021_acssuschemeng_2c04294 crossref_primary_10_1002_mabi_202000424 crossref_primary_10_1016_j_biomaterials_2020_120193 crossref_primary_10_1016_j_jconrel_2021_07_038 crossref_primary_10_1002_ange_202207250 crossref_primary_10_1002_advs_202304042 crossref_primary_10_1021_acs_chemrev_4c00241 crossref_primary_10_1016_j_nantod_2021_101266 crossref_primary_10_1063_5_0223718 crossref_primary_10_1016_j_jddst_2023_104312 crossref_primary_10_1016_j_colsurfb_2023_113529 crossref_primary_10_1021_acsami_0c22489 crossref_primary_10_1016_j_biomaterials_2022_121917 crossref_primary_10_1016_j_trac_2025_118188 crossref_primary_10_1016_j_cis_2023_103037 crossref_primary_10_1016_j_ccr_2023_215634 crossref_primary_10_1016_j_bioactmat_2024_06_010 crossref_primary_10_1016_j_biomaterials_2025_123113 crossref_primary_10_3390_targets1010006 crossref_primary_10_1002_advs_202204937 crossref_primary_10_1002_smtd_202200139 crossref_primary_10_1039_D4SC08685F crossref_primary_10_1016_j_jcis_2023_07_165 crossref_primary_10_1016_j_apmt_2024_102215 crossref_primary_10_1007_s12094_024_03577_3 crossref_primary_10_1021_acsnano_0c10388 crossref_primary_10_1016_j_colsurfb_2023_113612 crossref_primary_10_1002_adfm_202101297 crossref_primary_10_1016_j_actbio_2023_01_049 crossref_primary_10_1002_wnan_1960 crossref_primary_10_1016_j_actbio_2023_12_012 crossref_primary_10_1039_D3TB00839H crossref_primary_10_1038_s41578_022_00426_z crossref_primary_10_1039_D1QM00677K crossref_primary_10_1002_advs_202308546 crossref_primary_10_1016_j_cej_2024_151040 crossref_primary_10_1039_D1NA00857A crossref_primary_10_1039_D2TB02599J crossref_primary_10_1002_adfm_202311029 crossref_primary_10_3390_cells11203288 crossref_primary_10_1016_j_cej_2022_139887 crossref_primary_10_1016_j_nano_2024_102801 crossref_primary_10_1016_j_jconrel_2023_07_015 crossref_primary_10_1021_acsnano_2c06713 crossref_primary_10_1016_j_biomaterials_2024_122744 crossref_primary_10_1186_s12951_023_01802_9 crossref_primary_10_1039_D4TB00578C crossref_primary_10_1002_advs_202402256 crossref_primary_10_1021_acs_chemrev_3c00778 crossref_primary_10_1016_j_cej_2022_141091 crossref_primary_10_1021_acsbiomaterials_4c00586 crossref_primary_10_1002_advs_202105086 crossref_primary_10_1186_s12951_021_01078_x crossref_primary_10_1002_anie_202207250 crossref_primary_10_1002_adfm_202311857 crossref_primary_10_1016_j_cej_2022_136948 crossref_primary_10_1016_j_bioactmat_2024_03_001 crossref_primary_10_1016_j_bioadv_2023_213418 crossref_primary_10_1021_acsbiomaterials_4c01150 |
| Cites_doi | 10.1002/anie.201608732 10.1002/(SICI)1097-4636(2000)53:1<1::AID-JBM1>3.0.CO;2-R 10.1039/C4NR02453B 10.1021/acs.analchem.7b00135 10.1038/457036b 10.1021/jp025544x 10.1007/s10555-010-9227-2 10.1021/acsnano.5b05825 10.1021/acscentsci.9b00216 10.1007/s10753-009-9162-y 10.1063/1.3046187 10.1021/nl100996u 10.1038/84643 10.3390/ph3051507 10.1074/jbc.R115.642926 10.1002/anie.201205482 10.1016/j.jconrel.2013.10.014 10.1002/anie.201308899 10.1016/j.drudis.2006.07.005 10.1038/nrd3228 10.1038/ncomms12967 10.1039/C6CC00780E 10.1021/acsnano.7b01442 10.3109/14756366.2012.761608 10.1038/74680 10.1021/nl500388h 10.1021/ar800150g 10.1039/c2cs15340h 10.1021/acsnano.9b00345 10.1084/jem.20052267 10.1021/jacs.7b07492 10.1016/j.joule.2018.02.019 10.1016/j.mtchem.2019.06.001 10.1002/adma.201304497 10.1126/science.1232227 10.1016/j.canlet.2008.04.026 10.1016/j.semcancer.2004.06.006 10.1016/j.energy.2005.09.014 10.1002/adma.201703822 10.1021/cr400532z |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 American Chemical Society. Copyright © 2020 American Chemical Society 2020 American Chemical Society |
| Copyright_xml | – notice: Copyright © 2020 American Chemical Society. – notice: Copyright © 2020 American Chemical Society 2020 American Chemical Society |
| DBID | N~. AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.1021/acscentsci.9b01342 |
| DatabaseName | American Chemical Society (ACS) Open Access CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: N~. name: American Chemical Society (ACS) Open Access url: https://pubs.acs.org sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 2374-7951 |
| EndPage | 565 |
| ExternalDocumentID | oai_doaj_org_article_577bb6faea5341c294c3bb5f46308140 PMC7181317 32342005 10_1021_acscentsci_9b01342 b704190667 |
| Genre | Journal Article |
| GroupedDBID | 53G 5VS ABUCX ACS ADACO ADBBV AFEFF ALMA_UNASSIGNED_HOLDINGS BAWUL BCNDV DIK EBS FRP GROUPED_DOAJ HYE KQ8 N~. OK1 RPM VF5 XKZ AAFWJ AAYXX ABBLG ADHLV ADUCK AFPKN AOIJS CITATION M48 NPM 7X8 5PM |
| ID | FETCH-LOGICAL-a507t-7e9e97ad2df784435435e471f56e99fa3280ada98ccaf638998b793da21f75eb3 |
| IEDL.DBID | M48 |
| ISSN | 2374-7943 |
| IngestDate | Wed Aug 27 01:30:38 EDT 2025 Thu Aug 21 18:38:48 EDT 2025 Fri Jul 11 16:39:12 EDT 2025 Wed Feb 19 02:30:50 EST 2025 Tue Jul 01 04:21:04 EDT 2025 Thu Apr 24 23:06:55 EDT 2025 Thu Aug 27 22:10:25 EDT 2020 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | http://pubs.acs.org/page/policy/authorchoice_termsofuse.html Copyright © 2020 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a507t-7e9e97ad2df784435435e471f56e99fa3280ada98ccaf638998b793da21f75eb3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-9543-7763 0000-0001-6242-6005 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1021/acscentsci.9b01342 |
| PMID | 32342005 |
| PQID | 2395634321 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_577bb6faea5341c294c3bb5f46308140 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7181317 proquest_miscellaneous_2395634321 pubmed_primary_32342005 crossref_citationtrail_10_1021_acscentsci_9b01342 crossref_primary_10_1021_acscentsci_9b01342 acs_journals_10_1021_acscentsci_9b01342 |
| ProviderPackageCode | ACS ABUCX AFEFF VF5 XKZ N~. CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-04-22 |
| PublicationDateYYYYMMDD | 2020-04-22 |
| PublicationDate_xml | – month: 04 year: 2020 text: 2020-04-22 day: 22 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | ACS central science |
| PublicationTitleAlternate | ACS Cent. Sci |
| PublicationYear | 2020 |
| Publisher | American Chemical Society |
| Publisher_xml | – name: American Chemical Society |
| References | ref9/cit9 ref6/cit6 ref36/cit36 ref3/cit3 ref27/cit27 ref18/cit18 ref11/cit11 ref25/cit25 ref16/cit16 ref29/cit29 ref32/cit32 ref23/cit23 ref39/cit39 ref14/cit14 ref8/cit8 ref5/cit5 ref31/cit31 ref2/cit2 ref34/cit34 ref37/cit37 ref28/cit28 ref40/cit40 ref20/cit20 ref17/cit17 ref10/cit10 ref26/cit26 ref35/cit35 ref19/cit19 ref21/cit21 ref12/cit12 ref15/cit15 ref22/cit22 ref13/cit13 ref33/cit33 ref4/cit4 ref30/cit30 ref1/cit1 ref24/cit24 ref38/cit38 ref7/cit7 |
| References_xml | – ident: ref18/cit18 doi: 10.1002/anie.201608732 – ident: ref23/cit23 doi: 10.1002/(SICI)1097-4636(2000)53:1<1::AID-JBM1>3.0.CO;2-R – ident: ref35/cit35 doi: 10.1039/C4NR02453B – ident: ref33/cit33 doi: 10.1021/acs.analchem.7b00135 – ident: ref9/cit9 doi: 10.1038/457036b – ident: ref25/cit25 doi: 10.1021/jp025544x – ident: ref10/cit10 doi: 10.1007/s10555-010-9227-2 – ident: ref28/cit28 doi: 10.1021/acsnano.5b05825 – ident: ref12/cit12 doi: 10.1021/acscentsci.9b00216 – ident: ref17/cit17 doi: 10.1007/s10753-009-9162-y – ident: ref26/cit26 doi: 10.1063/1.3046187 – ident: ref4/cit4 doi: 10.1021/nl100996u – ident: ref40/cit40 doi: 10.1038/84643 – ident: ref39/cit39 doi: 10.3390/ph3051507 – ident: ref14/cit14 doi: 10.1074/jbc.R115.642926 – ident: ref22/cit22 doi: 10.1002/anie.201205482 – ident: ref7/cit7 doi: 10.1016/j.jconrel.2013.10.014 – ident: ref37/cit37 doi: 10.1002/anie.201308899 – ident: ref29/cit29 doi: 10.1016/j.drudis.2006.07.005 – ident: ref15/cit15 doi: 10.1038/nrd3228 – ident: ref3/cit3 doi: 10.1038/ncomms12967 – ident: ref27/cit27 doi: 10.1039/C6CC00780E – ident: ref24/cit24 doi: 10.1021/acsnano.7b01442 – ident: ref32/cit32 doi: 10.3109/14756366.2012.761608 – ident: ref16/cit16 doi: 10.1038/74680 – ident: ref38/cit38 doi: 10.1021/nl500388h – ident: ref5/cit5 doi: 10.1021/ar800150g – ident: ref6/cit6 doi: 10.1039/c2cs15340h – ident: ref20/cit20 doi: 10.1021/acsnano.9b00345 – ident: ref13/cit13 doi: 10.1084/jem.20052267 – ident: ref36/cit36 doi: 10.1021/jacs.7b07492 – ident: ref21/cit21 doi: 10.1016/j.joule.2018.02.019 – ident: ref30/cit30 doi: 10.1016/j.mtchem.2019.06.001 – ident: ref34/cit34 doi: 10.1002/adma.201304497 – ident: ref11/cit11 doi: 10.1126/science.1232227 – ident: ref1/cit1 doi: 10.1016/j.canlet.2008.04.026 – ident: ref8/cit8 doi: 10.1016/j.semcancer.2004.06.006 – ident: ref31/cit31 doi: 10.1016/j.energy.2005.09.014 – ident: ref19/cit19 doi: 10.1002/adma.201703822 – ident: ref2/cit2 doi: 10.1021/cr400532z |
| SSID | ssj0001466527 |
| Score | 2.4045453 |
| Snippet | Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT... Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT... |
| SourceID | doaj pubmedcentral proquest pubmed crossref acs |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 555 |
| SummonAdditionalLinks | – databaseName: American Chemical Society (ACS) Open Access dbid: N~. link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELaqcoAL4k0oICMhcQCXxHbs-FhWVAXRFYKt1FvkpxqJJmibVpy48b-ZSbJbFpUKKSfHzkSeGc9nex6EvDQlj5VKgSleWAYWPzCjg2LaCoEWGSwWRiMfztXBkfx4XB5vkTf_uMHnxVvrx7RGvtk1eGgnYcG9wVVVoRrOf-5enqhIpcYarVygk6GRYoqSufozaI_82YY9GtL2X4U1_3aZ_MMG7d8htyfwSPdGbt8lW7G9R27OVjXb7pNfcxBc9qFNS_Qrp59w502_TG6wF5HCWtoBSsSDegpolX5t0KHQthH2_3RxfgpNn0-6fojKOgVKizHnALVtoDO7dF1LYRHofjQhssOhyAdQ2Wv7BmmCbI1xkA_I0f77xeyATYUWmAU42DMdTTTaBh6SriQAKHgiWK1UqmhMsoJXuQ3WVMDuhBDHVA70OlheJF3Cdvwh2W67Nj4mtIoimYIrGOOkt8bqPHLlgqucz30hMvIKJr2eFOWsHu7AeVFfsqee2JORYsWY2k_5yrFsxrdrx7xej_k-Zuu4tvc75Pe6J2baHhpA_OpJcetSa-dUstGWYPA9N9IL58oklcgxW1hGXqykpQZm43XLyLWaC9h7YtxukZFHo_SsSQkO9GEBzIjekKuNf9l80zYnQ_ZvABMFqNCT_57IHXKL4yFBLhnnT8l2vzyPzwBJ9e75oEC_AePjHm4 priority: 102 providerName: American Chemical Society – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Ni9UwEA-6F72I39YvIggeJNombdIc14fLKu4i-hb2FpImYQtuKs-u-A_4fzvT9D3fE1kvQk9pw4TOZD6Smd8Q8lw3PLQyeiZ5ZRlYfM-08pIpKwRaZLBYWI18dCwPT-r3p83pVqsvzAnL8MD5x0HArpyT0QbbgMLtuK474VwTaylKRGtC7Qs2byuYmk5XaikbruYqGbBjr22X0ZG6_pXGsz_szX4VBnfs0QTb_zdf88-UyS0bdHCT3JidR7qfF32LXAnpNrm2WPdsu0N-HoPgsncprjCvnH7AyJt-mtNgvwcKunQALxEP6il4q_RzjwmFNgWI_-ny4hyGPp4N41SVdQ6UlhlzgNrk6cKu3JAoKIHhR-8DO5qafACV_TT2SBNkK9dB3iUnB2-Xi0M2N1pgFtzBkamgg1bWcx9VW4MDBU8AqxUbGbSOVvC2tN7qFtgd0cXRrYN97S2vomogHL9H9tKQwgNC2yCirriEOa7urLaqDFw671rXlV0lCvICfrqZN8o3M92B88r8Zo-Z2VOQas0Y08145dg248ulc15u5nzNaB2Xfv0G-b35EpG2pwGQPzPLn_mX_BXk2VpaDDAbr1sy1wwXEHti3W5VkPtZejakBAf6oAALonbkamctu29Sfzahf4MzUcEWevg_Fv-IXOd4flDWjPPHZG9cXYQn4GSN7um0n34BfskpNw priority: 102 providerName: Directory of Open Access Journals |
| Title | Near-Infrared Light Responsive Nanoreactor for Simultaneous Tumor Photothermal Therapy and Carbon Monoxide-Mediated Anti-Inflammation |
| URI | http://dx.doi.org/10.1021/acscentsci.9b01342 https://www.ncbi.nlm.nih.gov/pubmed/32342005 https://www.proquest.com/docview/2395634321 https://pubmed.ncbi.nlm.nih.gov/PMC7181317 https://doaj.org/article/577bb6faea5341c294c3bb5f46308140 |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3di9NAEF-O80FfxG_jaVlB8EFSk91kN_sgchaPU2wRr4V7C7vZXS9wl3hpK-eLb_7fzuSjWikHQslDmu00mZmd30zmg5AXKmUuE96GgsU6BItvQyWtCKXmHC0yWCysRp7OxPEi-Xianu6RYdxR_wCXO107nCe1aM7HV5c_3oLCv-kaD8SvddE1PirKscKwXgJb8g2wTBInGkx7uN_GXBIhuimujGMaokp4X0ez-2fQYhXLLYvVNvbfhUb_Tar8y0od3SG3e3hJDzt5uEv2XHWP3JwMU93uk18zEO3wQ-UbzDynn9A3p1_6RNnvjsJuWwOOxFA-BTxLT0pMOdSVq9dLOl9fwKnPZ_Wqrdu6AErzrisB1ZWlE92YuqKwTdRXpXXhtB0DAlQOq1WJNEH6ukrJB2Rx9H4-OQ77UQyhBsC4CqVTTkltmfUySwBiwceBXfOpcEp5zVkWaatVBgLhEQSpzIDmW81iL1Nw2B-S_aqu3GNCM8e9ipmANSYptNIyckwYazJTREXMA_ISHno-SELeviVncf6HPXnPnoDEA2Pyou9ojoM1zq9d82qz5lvXz-Paq98hvzdXYi_u9kTdfM171c5TKY0RXjudAiQomEoKbkzqE8Ej7CcWkOeDtOTAbHwh03EtZxy8U6zsjQPyqJOeDSnOgD5skQGRW3K19V-2v6nKs7Y_OMCNGJTsyX_d6gG5xTCUECUhY0_J_qpZu2eAt1ZmBP7G5GTURitGrULBcfZz_BtJKDCv |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Lb9MwGLfGOIwL4k0YDyOBOCCPxE6c-MBhFKaWtRWCTtrN2LGtRWLJ1KQ8Ltz4S_hH-ZykLUXTxGVST24cO_5eP9vfA6FnIqE2484QTiNFwOIbIlLDSaoY8xYZLJaPRp5M-fAofn-cHG-h38tYGJhEDW-q20v8dXaB6BW0tdmN8mJP-LO7mPaelIf2xzfYp9WvR2-BqM8pPXg3GwxJX0qAKAA8DUmtsCJVhhqXZjFABPhZ0Msu4VYIpxjNQmWUyOCDnDfiItPAuUbRyKUJbDjhvVfQVUA_iZf-6c-99UFOzHlXGpYy79soYtYH55w_bW8G83rDDLbVAs6DuP96av5l-g5uoOs9ZsX7HZPdRFu2vIV2BstScbfRrymsERmVbu7d2fHYb_jxx9779qvFoMIrAKf-fgADSMafCu_HqEpbLWo8W5xC04eTqmmDwU5hpFmX6gCr0uCBmuuqxKB7qu-FsWTS1haBUfbLpvBjAkt34Zd30NGlEOUu2i6r0t5HOLPMiYhy6KPjXAmVhpZybXSm8zCPWIBewKLLXj5r2V6900iuySN78gQoWhJG5n2adF-t48uFfV6u-px1SUIufPqNp_fqSZ_gu20Alpe9vpBJmmrNnbIqAZyRUxHnTOvExZyFPklZgJ4uuUUCsf0tT0c1SRlseX24cBSgex33rIZiFMYHvRugdIOvNuay-U9ZnLRJxwHDRCC5D_57IZ-gneFsMpbj0fRwF12j_pwijAmlD9F2M1_YRwDmGv24FSaMPl-29P4B_ZBeTQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Lb9MwGLfGkIAL4k14GgnEAXkkduLEBw6jo1rZVk3QSbt5dmxrlVgyNSmPCzf-Fv5NPiduR9E0cZnUkxvHjr_Xz_b3QOilyKgtuDOE00QRsPiGiNxwkivGvEUGi-WjkffGfPsg_XiYHa6h34tYGJhEA29qukt8L9WnxoUMA8lbaO8yHJXTDeHP71IavCl37I9vsFdr3o22gLCvKB1-mAy2SSgnQBSAnpbkVliRK0ONy4sUYAL8LOhml3ErhFOMFrEyShTwUc4bclFo4F6jaOLyDDad8N4r6Crgn9hrgPHPjbPDnJTzvjwsZd6_UaQsBOicP21vCstmxRR2FQPOg7n_emv-Zf6Gt9DNgFvxZs9ot9Gare6g64NFubi76NcY1oiMKjfzLu1412_68afggfvVYlDjNQBUf0eAASjjz1Pvy6gqW88bPJmfQNP-cd12AWEnMNKkT3eAVWXwQM10XWHQP_X3qbFkr6svAqNsVu3Ujwls3Ydg3kMHl0KU-2i9qiv7EOHCMicSyqGPTkslVB5byrXRhS7jMmEReg2LLoOMNrK7fqeJPCOPDOSJULIgjCxDqnRfsePLhX3eLPuc9olCLnz6vaf38kmf5LtrALaXQWfILM-15k5ZlQHWKKlIS6Z15lLOYp-oLEIvFtwigdj-pqenmqQMtr0-ZDiJ0IOee5ZDMQrjg-6NUL7CVytzWf2nmh53iccBxyQgvY_-eyGfo2v7W0O5OxrvPEY3qD-qiFNC6RO03s7m9inguVY_62QJo6PLFt4_9ONfWg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Near-Infrared+Light+Responsive+Nanoreactor+for+Simultaneous+Tumor+Photothermal+Therapy+and+Carbon+Monoxide-Mediated+Anti-Inflammation&rft.jtitle=ACS+central+science&rft.au=Wang%2C+Shi-Bo&rft.au=Zhang%2C+Cheng&rft.au=Ye%2C+Jing-Jie&rft.au=Zou%2C+Mei-Zhen&rft.date=2020-04-22&rft.issn=2374-7943&rft.eissn=2374-7951&rft.volume=6&rft.issue=4&rft.spage=555&rft.epage=565&rft_id=info:doi/10.1021%2Facscentsci.9b01342&rft.externalDBID=n%2Fa&rft.externalDocID=10_1021_acscentsci_9b01342 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2374-7943&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2374-7943&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2374-7943&client=summon |