The Bromodomain: A New Target in Emerging Epigenetic Medicine

• Published in: ACS chemical biology Vol. 11; no. 3; pp. 598 - 608
• Main Authors: Smith, Steven G, Zhou, Ming-Ming
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 18.03.2016
• Subjects: Conserved Sequence; Drug Delivery Systems; Epigenesis, Genetic; Humans; Lysine - chemistry; Lysine - metabolism; Protein Domains; Receptors, Fc

The bromodomain (BrD) is a conserved protein modular domain found in many chromatin- and transcription-associated proteins that has the ability to recognize acetylated lysine residues. This activity allows bromodomains to play a vital role in many acetylation-mediated protein–protein interactions in...