Synthesis and Evaluation of [N-methyl-11C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp Function - Lazarova, Neva; Zoghbi, Sami S; Hong, Jinsoo; Seneca, Nicholas; Tuan, Ed; Gladding, Robert L; Liow, Jeih-San; Taku, Andrew; Innis, Robert B; Pike, Victor W (Journal of medicinal chemistry, 2008)
Keywords: Animals; ATP Binding Cassette Transporter, Subfamily B - deficiency; ATP Binding Cassette Transporter, Subfamily B - metabolism; Biological and medical sciences; Brain - diagnostic imaging; Brain - metabolism; Carbon Radioisotopes; Chemistry, Medicinal; Contrast media. Radiopharmaceuticals; Injections, Intravenous; Life Sciences & Biomedicine; Loperamide - analogs & derivatives; Loperamide - chemical synthesis; Loperamide - chemistry; Loperamide - pharmacokinetics; Macaca mulatta; Male; Medical sciences; Mice; Mice, Knockout; Molecular Structure; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Positron-Emission Tomography - methods; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - pharmacokinetics; Science & Technology; Stereoisomerism; Time Factors; GLYCOPROTEIN FUNCTION; TRANSPORTER; RADIOMETABOLITE; IN-VIVO; LOPERAMIDE; OPIOID RECEPTORS; MULTIDRUG-RESISTANCE; BLOOD-BRAIN-BARRIER; EXPRESSION; MODULATION; Transmembrane protein; Loperamide; Intravenous administration; Radiolabelling; Rodentia; P Glycoprotein; Monkey; Central nervous system; Antidiarrheal agent; Carbon Isotopes; Vertebrata; Mammalia; Mouse; Scintigraphic agent; Animal; Piperidine derivatives; Primates; Carbon 11; Carboxamide; Chemical synthesis; Positron emission tomography; Carrier protein