Label-Free LC–MS/MS Proteomic Analysis of Cerebrospinal Fluid Identifies Protein/Pathway Alterations and Candidate Biomarkers for Amyotrophic Lateral Sclerosis

Analysis of the cerebrospinal fluid (CSF) proteome has proven valuable to the study of neurodegenerative disorders. To identify new protein/pathway alterations and candidate biomarkers for amyotrophic lateral sclerosis (ALS), we performed comparative proteomic profiling of CSF from sporadic ALS (sAL...

Full description

Saved in:
Bibliographic Details
Published inJournal of proteome research Vol. 14; no. 11; pp. 4486 - 4501
Main Authors Collins, Mahlon A, An, Jiyan, Hood, Brian L, Conrads, Thomas P, Bowser, Robert P
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 06.11.2015
Subjects
Adaptor Proteins, Signal Transducing - cerebrospinal fluid
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - isolation & purification
Adult
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - diagnosis
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Amyloid beta-Protein Precursor - cerebrospinal fluid
Amyloid beta-Protein Precursor - genetics
Amyloid beta-Protein Precursor - isolation & purification
amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - cerebrospinal fluid
Amyotrophic Lateral Sclerosis - diagnosis
Amyotrophic Lateral Sclerosis - genetics
Amyotrophic Lateral Sclerosis - pathology
biomarkers
Biomarkers - cerebrospinal fluid
Calcium-Binding Proteins - cerebrospinal fluid
Calcium-Binding Proteins - genetics
Calcium-Binding Proteins - isolation & purification
Case-Control Studies
cell adhesion molecules
Cell Adhesion Molecules - cerebrospinal fluid
Cell Adhesion Molecules - genetics
Cell Adhesion Molecules - isolation & purification
cerebrospinal fluid
Cerebrospinal Fluid Proteins - cerebrospinal fluid
Cerebrospinal Fluid Proteins - genetics
Cerebrospinal Fluid Proteins - isolation & purification
Chromatography, Liquid - methods
Diagnosis, Differential
extracellular matrix
Extracellular Matrix - chemistry
Extracellular Matrix Proteins - cerebrospinal fluid
Extracellular Matrix Proteins - genetics
Extracellular Matrix Proteins - isolation & purification
Humans
Immunoglobulins - cerebrospinal fluid
Immunoglobulins - genetics
Immunoglobulins - isolation & purification
Inflammation
liquid chromatography
Middle Aged
Motor Neuron Disease - cerebrospinal fluid
Motor Neuron Disease - diagnosis
Motor Neuron Disease - genetics
Motor Neuron Disease - pathology
neurons
proteome
Proteome - genetics
Proteome - isolation & purification
Proteome - metabolism
proteomics
Proteomics - methods
Sensitivity and Specificity
Support Vector Machine
support vector machines
Synapses - genetics
Synapses - metabolism
Synaptic Transmission
tandem mass spectrometry
Tandem Mass Spectrometry - methods
proteomics
cerebrospinal fluid
liquid chromatography-tandem mass spectrometry
mass spectrometry
biomarker
amyotrophic lateral sclerosis
extracellular matrix
LC−MS/MS
Online AccessGet full text

Cover

Abstract Analysis of the cerebrospinal fluid (CSF) proteome has proven valuable to the study of neurodegenerative disorders. To identify new protein/pathway alterations and candidate biomarkers for amyotrophic lateral sclerosis (ALS), we performed comparative proteomic profiling of CSF from sporadic ALS (sALS), healthy control (HC), and other neurological disease (OND) subjects using label-free liquid chromatography-tandem mass spectrometry (LC–MS/MS). A total of 1712 CSF proteins were detected and relatively quantified by spectral counting. Levels of several proteins with diverse biological functions were significantly altered in sALS samples. Enrichment analysis was used to link these alterations to biological pathways, which were predominantly related to inflammation, neuronal activity, and extracellular matrix regulation. We then used our CSF proteomic profiles to create a support vector machines classifier capable of discriminating training set ALS from non-ALS (HC and OND) samples. Four classifier proteins, WD repeat-containing protein 63, amyloid-like protein 1, SPARC-like protein 1, and cell adhesion molecule 3, were identified by feature selection and externally validated. The resultant classifier distinguished ALS from non-ALS samples with 83% sensitivity and 100% specificity in an independent test set. Collectively, our results illustrate the utility of CSF proteomic profiling for identifying ALS protein/pathway alterations and candidate disease biomarkers.
AbstractList Analysis of the cerebrospinal fluid (CSF) proteome has proven valuable to the study of neurodegenerative disorders. To identify new protein/pathway alterations and candidate biomarkers for amyotrophic lateral sclerosis (ALS), we performed comparative proteomic profiling of CSF from sporadic ALS (sALS), healthy control (HC), and other neurological disease (OND) subjects using label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total of 1712 CSF proteins were detected and relatively quantified by spectral counting. Levels of several proteins with diverse biological functions were significantly altered in sALS samples. Enrichment analysis was used to link these alterations to biological pathways, which were predominantly related to inflammation, neuronal activity, and extracellular matrix regulation. We then used our CSF proteomic profiles to create a support vector machines classifier capable of discriminating training set ALS from non-ALS (HC and OND) samples. Four classifier proteins, WD repeat-containing protein 63, amyloid-like protein 1, SPARC-like protein 1, and cell adhesion molecule 3, were identified by feature selection and externally validated. The resultant classifier distinguished ALS from non-ALS samples with 83% sensitivity and 100% specificity in an independent test set. Collectively, our results illustrate the utility of CSF proteomic profiling for identifying ALS protein/pathway alterations and candidate disease biomarkers.Analysis of the cerebrospinal fluid (CSF) proteome has proven valuable to the study of neurodegenerative disorders. To identify new protein/pathway alterations and candidate biomarkers for amyotrophic lateral sclerosis (ALS), we performed comparative proteomic profiling of CSF from sporadic ALS (sALS), healthy control (HC), and other neurological disease (OND) subjects using label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total of 1712 CSF proteins were detected and relatively quantified by spectral counting. Levels of several proteins with diverse biological functions were significantly altered in sALS samples. Enrichment analysis was used to link these alterations to biological pathways, which were predominantly related to inflammation, neuronal activity, and extracellular matrix regulation. We then used our CSF proteomic profiles to create a support vector machines classifier capable of discriminating training set ALS from non-ALS (HC and OND) samples. Four classifier proteins, WD repeat-containing protein 63, amyloid-like protein 1, SPARC-like protein 1, and cell adhesion molecule 3, were identified by feature selection and externally validated. The resultant classifier distinguished ALS from non-ALS samples with 83% sensitivity and 100% specificity in an independent test set. Collectively, our results illustrate the utility of CSF proteomic profiling for identifying ALS protein/pathway alterations and candidate disease biomarkers.
Analysis of the cerebrospinal fluid (CSF) proteome has proven valuable to the study of neurodegenerative disorders. To identify new protein/pathway alterations and candidate biomarkers for amyotrophic lateral sclerosis (ALS), we performed comparative proteomic profiling of CSF from sporadic ALS (sALS), healthy control (HC), and other neurological disease (OND) subjects using label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total of 1,712 CSF proteins were detected and relatively quantified by spectral counting. Levels of several proteins with diverse biological functions were significantly altered in sALS samples. Enrichment analysis was used to link these alterations to biological pathways, which were predominantly related to inflammation, neuronal activity, and extracellular matrix regulation. We then used our CSF proteomic profiles to create a support vector machines classifier capable of discriminating training set ALS from non-ALS (HC and OND) samples. Four classifier proteins, WD repeat-containing protein 63, amyloid-like protein 1, SPARC-like protein 1, and cell adhesion molecule 3 were identified by feature selection and externally validated. The resultant classifier distinguished ALS from non-ALS samples with 83% sensitivity and 100% specificity in an independent test set. Collectively, our results illustrate the utility of CSF proteomic profiling for identifying ALS protein/pathway alterations and candidate disease biomarkers.
Analysis of the cerebrospinal fluid (CSF) proteome has proven valuable to the study of neurodegenerative disorders. To identify new protein/pathway alterations and candidate biomarkers for amyotrophic lateral sclerosis (ALS), we performed comparative proteomic profiling of CSF from sporadic ALS (sALS), healthy control (HC), and other neurological disease (OND) subjects using label-free liquid chromatography-tandem mass spectrometry (LC–MS/MS). A total of 1712 CSF proteins were detected and relatively quantified by spectral counting. Levels of several proteins with diverse biological functions were significantly altered in sALS samples. Enrichment analysis was used to link these alterations to biological pathways, which were predominantly related to inflammation, neuronal activity, and extracellular matrix regulation. We then used our CSF proteomic profiles to create a support vector machines classifier capable of discriminating training set ALS from non-ALS (HC and OND) samples. Four classifier proteins, WD repeat-containing protein 63, amyloid-like protein 1, SPARC-like protein 1, and cell adhesion molecule 3, were identified by feature selection and externally validated. The resultant classifier distinguished ALS from non-ALS samples with 83% sensitivity and 100% specificity in an independent test set. Collectively, our results illustrate the utility of CSF proteomic profiling for identifying ALS protein/pathway alterations and candidate disease biomarkers.
Author Collins, Mahlon A
An, Jiyan
Conrads, Thomas P
Bowser, Robert P
Hood, Brian L
AuthorAffiliation Barrow Neurological Institute
University of Pittsburgh
Departments of Neurology and Neurobiology
Women’s Health Integrated Research Center
Department of Neurobiology
AuthorAffiliation_xml – name: Barrow Neurological Institute
– name: Departments of Neurology and Neurobiology
– name: Women’s Health Integrated Research Center
– name: Department of Neurobiology
– name: University of Pittsburgh
– name: Departments of Neurology and Neurobiology, Barrow Neurological Institute, NRC427, 350 West Thomas Road, Phoenix, AZ, USA 85013
– name: Women’s Health Integrated Research Center, 3289 Woodburn Road, Annandale, VA, USA 22003
– name: Department of Neurobiology, University of Pittsburgh, E1448 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA, USA 15261
Author_xml – sequence: 1
  givenname: Mahlon A
  surname: Collins
  fullname: Collins, Mahlon A
– sequence: 2
  givenname: Jiyan
  surname: An
  fullname: An, Jiyan
– sequence: 3
  givenname: Brian L
  surname: Hood
  fullname: Hood, Brian L
– sequence: 4
  givenname: Thomas P
  surname: Conrads
  fullname: Conrads, Thomas P
– sequence: 5
  givenname: Robert P
  surname: Bowser
  fullname: Bowser, Robert P
  email: Robert.Bowser@dignityhealth.org
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26401960$$D View this record in MEDLINE/PubMed
BookMark eNqFUstu1DAUjVARfcAngLxkkxk7jvMQEtIQMVApFZUG1pbjXDMuSRxsBzS7_kO_gF_jS3Cb6QjYzMa2fM8591z7nEcngxkgil4SvCA4IUsh3eJmtMaD6WHBGowLnD6JzgijLKYlzk8ez0VJT6Nz524wJizH9Fl0mmQpJmWGz6JftWigi9cWANXV79u7q83yaoOuZ2Et0WoQ3c5ph4xCFVhorHGjDpdo3U26RZctDF4rDW4m6WF5Lfz2p9ihVefBCq_N4JAYWlSFRbfCA3qnTS_sN7AOKWPRqt8Zb824Df1qcU_q0EZ2EFpp9zx6qkTn4MV-v4i-rN9_rj7G9acPl9WqjgXDzMeKpkWmmjJvMKVYtkULGbBWgBCNKvKMNm0GSuRKKgKiTEua0wayPJVpmxdNQi-it7PuODU9tDKMFXzw0epgdceN0PzfyqC3_Kv5wRkrk5xmQeD1XsCa7xM4z3vtJHSdGMBMjieY0aII2OIolOSUBBgjOEBf_W3r4OfxCwOAzQAZnstZUAcIwfw-KjxEhR-iwvdRCbw3__Gk9g-_FabT3VE2mdkPZTPZkAh3hPMHDZ3g9w
CitedBy_id crossref_primary_10_3390_ijms23116218
crossref_primary_10_1136_jnnp_2019_321916
crossref_primary_10_1002_sctm_18_0154
crossref_primary_10_1016_j_neuron_2021_11_025
crossref_primary_10_1038_s41419_017_0106_4
crossref_primary_10_7759_cureus_76027
crossref_primary_10_1126_sciadv_adk9884
crossref_primary_10_3233_JAD_220360
crossref_primary_10_1016_j_neures_2019_10_010
crossref_primary_10_3390_cells9122642
crossref_primary_10_1016_j_jprot_2023_104820
crossref_primary_10_1080_14789450_2017_1365602
crossref_primary_10_3390_biomedicines11051250
crossref_primary_10_1371_journal_pone_0178608
crossref_primary_10_1002_alz_12970
crossref_primary_10_1002_ibra_12036
crossref_primary_10_3390_cells10020249
crossref_primary_10_1080_14789450_2021_2004890
crossref_primary_10_1093_brain_awac077
crossref_primary_10_1097_WCO_0000000000000744
crossref_primary_10_1080_15622975_2017_1375556
crossref_primary_10_1080_21678421_2018_1433689
crossref_primary_10_1371_journal_pone_0302280
crossref_primary_10_1080_14789450_2017_1307106
crossref_primary_10_1186_s13048_018_0460_6
crossref_primary_10_1016_j_smrv_2023_101789
crossref_primary_10_1016_j_vesic_2025_100071
crossref_primary_10_1080_21678421_2016_1267768
crossref_primary_10_2174_0113892037293525240621120033
crossref_primary_10_15252_embj_201694221
crossref_primary_10_1016_j_tins_2022_03_004
crossref_primary_10_3389_fnins_2019_00548
crossref_primary_10_1016_j_isci_2021_103221
crossref_primary_10_3390_ijms23169161
crossref_primary_10_1111_jnc_16030
crossref_primary_10_3390_proteomes11010001
crossref_primary_10_3389_fnagi_2022_866886
crossref_primary_10_1080_14789450_2016_1219254
crossref_primary_10_1007_s12035_018_0947_6
crossref_primary_10_1080_21678421_2021_1885448
crossref_primary_10_1002_prca_201700043
crossref_primary_10_1155_2020_5849323
crossref_primary_10_15252_embr_202050640
crossref_primary_10_1186_s40478_020_00968_9
crossref_primary_10_1007_s13311_016_0503_x
crossref_primary_10_1093_bib_bbz160
crossref_primary_10_1038_s41598_018_34642_x
crossref_primary_10_1016_j_isci_2024_109891
crossref_primary_10_1515_cclm_2019_0428
crossref_primary_10_1186_s13287_018_0890_5
crossref_primary_10_1038_s41598_017_07127_6
crossref_primary_10_1016_j_tins_2021_02_008
crossref_primary_10_3390_proteomes6030032
crossref_primary_10_3389_fneur_2019_00291
crossref_primary_10_1002_ana_25143
crossref_primary_10_1016_j_jprot_2018_11_005
crossref_primary_10_1096_fj_201600259RR
crossref_primary_10_3390_biomedicines11112967
crossref_primary_10_1007_s00216_020_02765_8
crossref_primary_10_1089_rej_2017_1946
crossref_primary_10_1038_s41467_022_35494_w
crossref_primary_10_3390_molecules27082411
crossref_primary_10_3389_fncel_2022_838432
crossref_primary_10_1016_j_neurobiolaging_2020_03_013
crossref_primary_10_1080_10408363_2017_1299682
crossref_primary_10_3389_fneur_2021_750543
crossref_primary_10_1186_s40035_022_00331_z
crossref_primary_10_1186_s12920_017_0274_1
crossref_primary_10_1155_2019_3283629
crossref_primary_10_3390_genes14020325
crossref_primary_10_3389_fneur_2021_792227
crossref_primary_10_3389_fnins_2020_577755
crossref_primary_10_3390_brainsci8120212
crossref_primary_10_4103_1673_5374_284980
Cites_doi 10.1242/jcs.01656
10.55782/ane-2009-1766
10.1007/s00401-012-1055-8
10.1111/j.1471-4159.2005.03478.x
10.1371/journal.pone.0064314
10.1111/j.2517-6161.1995.tb02031.x
10.1126/science.286.5439.531
10.1074/mcp.M600274-MCP200
10.1039/b610957h
10.1007/s00415-013-7112-y
10.1016/0304-3940(96)12314-4
10.1002/pmic.200400889
10.1093/nar/28.18.3442
10.1111/j.1600-0404.1996.tb07063.x
10.1073/pnas.1013699108
10.1177/030006051204000622
10.1016/j.jneumeth.2015.05.011
10.1016/j.biopsych.2013.11.032
10.3109/17482968.2012.724074
10.1371/journal.pone.0015133
10.1136/jnnp.2009.183525
10.1002/pmic.201200002
10.1073/pnas.1530509100
10.1007/s00401-012-1058-5
10.1016/j.jprot.2013.05.030
10.1007/s00401-008-0456-1
10.1021/pr100904q
10.1212/01.wnl.0000203129.82104.07
10.1111/j.1600-0404.1985.tb01548.x
10.1007/s00401-011-0911-2
10.1136/jnnp-2014-308946
10.1007/978-0-387-78952-1_11
10.1056/NEJM199403033300901
10.1093/bioinformatics/btm344
10.1016/j.bbrc.2006.02.051
10.1038/nmeth1019
10.1093/nar/gkg034
10.3109/21678421.2014.887733
10.1007/s13361-011-0237-2
10.1073/pnas.091062498
10.1371/journal.pone.0044401
10.1093/hmg/ddp498
10.1016/j.neurol.2013.07.019
10.1021/ac901335x
10.1038/nrneurol.2013.10
10.1093/bioinformatics/btp677
10.1016/0002-9343(83)90080-3
10.1038/nm.2901
10.1186/2043-9113-3-1
10.1097/NEN.0000000000000086
10.1016/j.mcn.2014.06.004
10.1038/nrneurol.2011.151
10.1016/j.neuroscience.2010.06.057
10.1074/jbc.M109.036285
10.1101/gr.1239303
10.1093/bioinformatics/bti565
10.1016/j.jneuroim.2009.09.002
10.1016/j.jneuroim.2014.09.005
10.1073/pnas.1104977108
10.1007/s004010050426
10.1016/j.jneuroim.2011.03.011
10.1016/j.bbamem.2008.03.013
10.1111/j.1467-9868.2004.00439.x
10.1002/stem.1812
10.1002/cbin.10092
10.1007/s00401-008-0408-9
10.1186/1742-2094-10-119
10.1007/978-1-60761-175-2_6
10.1371/journal.pone.0013250
10.1111/1467-9868.00346
10.1007/978-0-387-09595-0_3
10.1023/A:1012487302797
10.1016/S1474-4422(13)70036-X
10.1021/ac0498563
10.3109/17482968.2010.541263
10.4238/vol7-2gmr426
10.1111/jnc.13063
10.1093/bioinformatics/btl633
10.1007/s12031-010-9467-1
10.1111/cge.12117
10.1093/bioinformatics/btp101
10.1212/WNL.50.1.66
10.1016/S0140-6736(10)61156-7
10.1110/ps.9.12.2470
10.1016/1044-0305(94)80016-2
10.1016/j.neulet.2009.10.053
10.1371/journal.pone.0087293
10.1111/j.1471-4159.2011.07224.x
10.1016/j.mcn.2006.03.002
10.1038/cddis.2014.25
10.1002/ana.22633
10.1074/jbc.M212291200
10.3109/00207454.2013.848440
10.1155/2012/908724
10.3109/17482968.2010.550302
10.1371/journal.pone.0010980
10.1093/bioinformatics/btt019
10.1002/cne.22627
10.1007/s00401-012-1045-x
10.1016/j.neulet.2009.01.026
10.1007/s00441-012-1375-y
10.1021/pr049750o
10.1145/1656274.1656278
10.1159/000107704
10.1038/75556
10.1042/BA20080015
10.1074/mcp.M500084-MCP200
10.1002/pmic.200400871
ContentType Journal Article
Copyright Copyright © 2015 American Chemical Society
Copyright_xml – notice: Copyright © 2015 American Chemical Society
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
5PM
DOI 10.1021/acs.jproteome.5b00804
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList MEDLINE - Academic

AGRICOLA

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1535-3907
EndPage 4501
ExternalDocumentID PMC5592736
26401960
10_1021_acs_jproteome_5b00804
a448670479
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NINDS NIH HHS
  grantid: F31NS080614-01
– fundername: NINDS NIH HHS
  grantid: RC1 NS068179
– fundername: NINDS NIH HHS
  grantid: F31 NS080614
– fundername: NINDS NIH HHS
  grantid: R56 NS061867
– fundername: NINDS NIH HHS
  grantid: R01 NS061867
– fundername: NINDS NIH HHS
  grantid: NS068179
– fundername: NINDS NIH HHS
  grantid: NS061867
GroupedDBID -
53G
55A
5GY
7~N
AABXI
ABMVS
ABUCX
ACGFS
ACS
AEESW
AENEX
AFEFF
ALMA_UNASSIGNED_HOLDINGS
AQSVZ
CS3
DU5
EBS
ED
ED~
EJD
F5P
GNL
IH9
IHE
JG
JG~
LG6
P2P
RNS
ROL
UI2
VF5
VG9
W1F
ZA5
---
4.4
5VS
AAHBH
AAYXX
ABBLG
ABJNI
ABLBI
ABQRX
ADHLV
AHGAQ
BAANH
CITATION
CUPRZ
GGK
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
5PM
ID FETCH-LOGICAL-a505t-f3486fb97b0330cd8de6e5daeaabf8763bd6efa7fcf1ea949373be674c4d78b23
IEDL.DBID ACS
ISSN 1535-3893
1535-3907
IngestDate Thu Aug 21 13:56:12 EDT 2025
Fri Jul 11 14:59:42 EDT 2025
Thu Jul 10 23:01:23 EDT 2025
Mon Jul 21 05:49:46 EDT 2025
Tue Jul 01 01:36:33 EDT 2025
Thu Apr 24 23:10:14 EDT 2025
Thu Aug 27 13:41:59 EDT 2020
IsPeerReviewed true
IsScholarly true
Issue 11
Keywords proteomics
cerebrospinal fluid
liquid chromatography-tandem mass spectrometry
mass spectrometry
biomarker
amyotrophic lateral sclerosis
extracellular matrix
LC−MS/MS
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a505t-f3486fb97b0330cd8de6e5daeaabf8763bd6efa7fcf1ea949373be674c4d78b23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 26401960
PQID 1731783510
PQPubID 23479
PageCount 16
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5592736
proquest_miscellaneous_2053889278
proquest_miscellaneous_1731783510
pubmed_primary_26401960
crossref_primary_10_1021_acs_jproteome_5b00804
crossref_citationtrail_10_1021_acs_jproteome_5b00804
acs_journals_10_1021_acs_jproteome_5b00804
ProviderPackageCode JG~
55A
AABXI
GNL
VF5
7~N
VG9
W1F
ACS
AEESW
AFEFF
ABMVS
ABUCX
IH9
AQSVZ
ED~
UI2
CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2015-11-06
PublicationDateYYYYMMDD 2015-11-06
PublicationDate_xml – month: 11
  year: 2015
  text: 2015-11-06
  day: 06
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Journal of proteome research
PublicationTitleAlternate J. Proteome Res
PublicationYear 2015
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
References ref45/cit45
ref99/cit99
ref3/cit3
ref81/cit81
ref16/cit16
ref52/cit52
ref23/cit23
ref110/cit110
ref111/cit111
ref2/cit2
ref112/cit112
ref77/cit77
ref71/cit71
ref20/cit20
ref48/cit48
ref74/cit74
Benjamini Y. (ref47/cit47) 1995; 1
ref10/cit10
ref35/cit35
ref89/cit89
ref19/cit19
ref93/cit93
ref42/cit42
ref107/cit107
ref109/cit109
ref13/cit13
ref105/cit105
ref61/cit61
ref67/cit67
ref38/cit38
ref90/cit90
ref64/cit64
ref54/cit54
ref6/cit6
ref18/cit18
ref65/cit65
ref97/cit97
ref101/cit101
ref11/cit11
ref102/cit102
ref29/cit29
ref86/cit86
ref32/cit32
ref39/cit39
ref5/cit5
ref43/cit43
ref80/cit80
ref28/cit28
Cushing H. (ref76/cit76) 1914; 31
ref91/cit91
Thijs V. (ref4/cit4) 2000; 100
ref55/cit55
ref12/cit12
ref66/cit66
ref22/cit22
ref33/cit33
ref87/cit87
ref106/cit106
ref44/cit44
ref70/cit70
ref98/cit98
ref9/cit9
ref27/cit27
ref63/cit63
ref56/cit56
ref92/cit92
ref8/cit8
ref31/cit31
ref59/cit59
ref85/cit85
ref34/cit34
ref37/cit37
ref60/cit60
ref88/cit88
ref17/cit17
ref82/cit82
Karetko M. (ref96/cit96) 2009; 69
ref53/cit53
ref21/cit21
ref46/cit46
ref49/cit49
ref75/cit75
ref24/cit24
ref50/cit50
ref78/cit78
ref36/cit36
ref83/cit83
ref79/cit79
ref100/cit100
ref25/cit25
ref103/cit103
ref72/cit72
ref14/cit14
ref57/cit57
ref51/cit51
ref40/cit40
ref68/cit68
ref94/cit94
ref26/cit26
ref69/cit69
ref15/cit15
ref62/cit62
ref41/cit41
ref58/cit58
ref95/cit95
ref108/cit108
ref104/cit104
ref30/cit30
ref84/cit84
ref1/cit1
ref7/cit7
21344998 - Amyotroph Lateral Scler. 2011 May;12(3):199-205
24625978 - Cell Death Dis. 2014 Mar 13;5:e1119
17182697 - Bioinformatics. 2007 Feb 15;23(4):401-7
21788491 - Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):E440-9
22675362 - Int J Cell Biol. 2012;2012:908724
21501881 - J Neuroimmunol. 2011 Jun;235(1-2):104-9
24571628 - Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):269-74
23505055 - Cell Biol Int. 2013 Jul;37(7):731-6
22970211 - PLoS One. 2012;7(9):e44401
21057983 - J Mol Neurosci. 2011 Mar;43(3):470-7
23317455 - J Clin Bioinforma. 2013 Jan 14;3(1):1
23325622 - Bioinformatics. 2013 Mar 1;29(5):661-3
16313519 - J Neurochem. 2005 Dec;95(5):1461-71
21300890 - Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3342-7
24475266 - PLoS One. 2014 Jan 27;9(1):e87293
21028795 - J Proteome Res. 2010 Dec 3;9(12):6091-100
19237447 - Bioinformatics. 2009 Apr 15;25(8):1091-3
19597782 - Methods Mol Biol. 2009;563:99-121
23143228 - Acta Neuropathol. 2013 Jan;125(1):95-109
16481598 - Neurology. 2006 Apr 25;66(8):1218-22
15741237 - J Cell Sci. 2005 Mar 15;118(Pt 6):1267-77
21456004 - J Comp Neurol. 2011 Aug 1;519(11):2252-70
17513293 - Mol Cell Proteomics. 2007 Aug;6(8):1354-64
19972189 - J Med Res. 1914 Sep;31(1):1-19
23770383 - J Proteomics. 2013 Dec 16;95:55-65
15253663 - Anal Chem. 2004 Jul 15;76(14):4193-201
20552007 - PLoS One. 2010 Jun 11;5(6):e10980
20948999 - PLoS One. 2010 Oct 11;5(10):e13250
11206068 - Protein Sci. 2000 Dec;9(12):2470-6
22922411 - Nat Med. 2012 Sep;18(9):1418-22
23379621 - Clin Genet. 2013 May;83(5):408-16
21952779 - J Am Soc Mass Spectrom. 2011 Dec;22(12):2199-208
23415570 - Lancet Neurol. 2013 Mar;12(3):310-22
17124542 - Analyst. 2006 Dec;131(12):1335-41
9443459 - Neurology. 1998 Jan;50(1):66-72
16677822 - Mol Cell Neurosci. 2006 May-Jun;32(1-2):102-17
15979981 - Mol Cell Proteomics. 2005 Oct;4(10):1487-502
18420026 - Biochim Biophys Acta. 2008 Jun;1778(6):1429-35
6349337 - Am J Med. 1983 Jul 28;75(1B):102-8
19025120 - Adv Exp Med Biol. 2008;632:143-58
17934327 - Neurodegener Dis. 2007;4(6):431-42
22684992 - Proteomics. 2012 Aug;12(14):2378-90
21296405 - Lancet. 2011 Mar 12;377(9769):942-55
24066851 - Int J Neurosci. 2014 May;124(5):344-9
21418221 - J Neurochem. 2011 May;117(3):528-37
8937538 - Acta Neurol Scand. 1996 Oct;94(4):264-8
24085347 - J Neurol. 2013 Nov;260(11):2917-27
12519996 - Nucleic Acids Res. 2003 Jan 1;31(1):258-61
10982861 - Nucleic Acids Res. 2000 Sep 15;28(18):3442-4
22437874 - Cell Tissue Res. 2012 Jul;349(1):147-60
22101323 - Acta Neuropathol. 2011 Dec;122(6):691-702
25644224 - J Neurol Neurosurg Psychiatry. 2015 Jun;86(6):667-73
17327847 - Nat Methods. 2007 Mar;4(3):207-14
22522477 - Ann Neurol. 2012 May;71(5):614-23
15672452 - Proteomics. 2005 Jan;5(1):290-6
19444952 - Neurosci Lett. 2009 Mar 6;452(1):52-5
19864493 - Hum Mol Genet. 2010 Jan 15;19(2):313-28
24226387 - J Am Soc Mass Spectrom. 1994 Nov;5(11):976-89
10934559 - Acta Neurol Belg. 2000 Jun;100(2):84-90
19853641 - Neurosci Lett. 2010 Jan 1;468(1):23-7
19710046 - J Neurol Neurosurg Psychiatry. 2010 Apr;81(4):385-90
8302340 - N Engl J Med. 1994 Mar 3;330(9):585-91
22985433 - Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr;14 (3):199-204
19850929 - J Biol Chem. 2009 Dec 18;284(51):35597-604
18551400 - Genet Mol Res. 2008 Apr 15;7(2):342-56
4050318 - Acta Neurol Scand. 1985 Jul;72(1):61-4
19782408 - J Neuroimmunol. 2010 Feb 26;219(1-2):1-7
17720704 - Bioinformatics. 2007 Oct 1;23(19):2507-17
21151566 - PLoS One. 2010 Dec 09;5(12):e15133
10802651 - Nat Genet. 2000 May;25(1):25-9
18989684 - Acta Neuropathol. 2009 Jan;117(1):55-62
11309499 - Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21
22992788 - Oncol Rep. 2012 Dec;28(6):2233-8
21126161 - Amyotroph Lateral Scler. 2011 Mar;12(2):140-3
24548642 - Biol Psychiatry. 2014 May 1;75(9):723-31
8929976 - Neurosci Lett. 1996 Feb 2;204(1-2):53-6
18607609 - Acta Neuropathol. 2008 Aug;116(2):205-13
26004848 - J Neurosci Methods. 2015 Aug 15;251:72-82
20007255 - Bioinformatics. 2010 Feb 1;26(3):363-9
8834540 - Acta Neuropathol. 1996;91(3):278-83
23419373 - Nat Rev Neurol. 2013 Mar;9(3):131-40
24918638 - J Neuropathol Exp Neurol. 2014 Jul;73(7):702-13
21989244 - Nat Rev Neurol. 2011 Oct 11;7(11):631-8
25262158 - J Neuroimmunol. 2014 Nov 15;276(1-2):213-8
24067070 - J Neuroinflammation. 2013 Sep 26;10 :119
18412540 - Biotechnol Appl Biochem. 2009 Feb;52(Pt 2):159-66
25113670 - Stem Cells. 2014 Dec;32(12):3163-72
22993125 - Acta Neuropathol. 2012 Nov;124(5):717-32
24998676 - Mol Cell Neurosci. 2014 Jul;61:201-10
16516157 - Biochem Biophys Res Commun. 2006 Apr 21;342(4):1034-9
20600637 - Neuroscience. 2010 Sep 29;170(1):289-97
12883005 - Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5
23700471 - PLoS One. 2013 May 20;8(5):e64314
15540204 - Proteomics. 2004 Dec;4(12):4010-8
24011641 - Rev Neurol (Paris). 2013 Oct;169(10):793-8
20048772 - Acta Neurobiol Exp (Wars). 2009;69(4):564-77
12538579 - J Biol Chem. 2003 Mar 28;278(13):11351-8
15994189 - Bioinformatics. 2005 Sep 15;21(18):3587-95
23124365 - Acta Neuropathol. 2013 Jan;125(1):121-31
19839595 - Anal Chem. 2009 Dec 1;81(23):9819-23
18925368 - Subcell Biochem. 2008;48:20-30
25683482 - J Neurochem. 2015 Jun;133(6):879-85
15952730 - J Proteome Res. 2005 May-Jun;4(3):837-45
10521349 - Science. 1999 Oct 15;286(5439):531-7
14597658 - Genome Res. 2003 Nov;13(11):2498-504
References_xml – ident: ref107/cit107
  doi: 10.1242/jcs.01656
– volume: 69
  start-page: 564
  year: 2009
  ident: ref96/cit96
  publication-title: Acta Neurobiol. Exp.
  doi: 10.55782/ane-2009-1766
– ident: ref100/cit100
  doi: 10.1007/s00401-012-1055-8
– ident: ref38/cit38
  doi: 10.1111/j.1471-4159.2005.03478.x
– ident: ref37/cit37
  doi: 10.1371/journal.pone.0064314
– volume: 1
  start-page: 289
  year: 1995
  ident: ref47/cit47
  publication-title: J. R. Stat. Soc.
  doi: 10.1111/j.2517-6161.1995.tb02031.x
– ident: ref65/cit65
  doi: 10.1126/science.286.5439.531
– ident: ref52/cit52
  doi: 10.1074/mcp.M600274-MCP200
– ident: ref53/cit53
  doi: 10.1039/b610957h
– ident: ref10/cit10
  doi: 10.1007/s00415-013-7112-y
– ident: ref91/cit91
  doi: 10.1016/0304-3940(96)12314-4
– ident: ref43/cit43
  doi: 10.1002/pmic.200400889
– ident: ref62/cit62
  doi: 10.1093/nar/28.18.3442
– ident: ref6/cit6
  doi: 10.1111/j.1600-0404.1996.tb07063.x
– ident: ref34/cit34
  doi: 10.1073/pnas.1013699108
– ident: ref32/cit32
  doi: 10.1177/030006051204000622
– ident: ref68/cit68
  doi: 10.1016/j.jneumeth.2015.05.011
– ident: ref21/cit21
  doi: 10.1016/j.biopsych.2013.11.032
– ident: ref25/cit25
  doi: 10.3109/17482968.2012.724074
– ident: ref71/cit71
  doi: 10.1371/journal.pone.0015133
– ident: ref1/cit1
  doi: 10.1136/jnnp.2009.183525
– ident: ref33/cit33
  doi: 10.1002/pmic.201200002
– ident: ref48/cit48
  doi: 10.1073/pnas.1530509100
– ident: ref81/cit81
  doi: 10.1007/s00401-012-1058-5
– ident: ref45/cit45
  doi: 10.1016/j.jprot.2013.05.030
– ident: ref19/cit19
  doi: 10.1007/s00401-008-0456-1
– ident: ref15/cit15
  doi: 10.1021/pr100904q
– ident: ref39/cit39
  doi: 10.1212/01.wnl.0000203129.82104.07
– ident: ref82/cit82
  doi: 10.1111/j.1600-0404.1985.tb01548.x
– ident: ref101/cit101
  doi: 10.1007/s00401-011-0911-2
– ident: ref13/cit13
  doi: 10.1136/jnnp-2014-308946
– ident: ref87/cit87
  doi: 10.1007/978-0-387-78952-1_11
– ident: ref8/cit8
  doi: 10.1056/NEJM199403033300901
– ident: ref31/cit31
  doi: 10.1093/bioinformatics/btm344
– ident: ref84/cit84
  doi: 10.1016/j.bbrc.2006.02.051
– ident: ref44/cit44
  doi: 10.1038/nmeth1019
– ident: ref63/cit63
  doi: 10.1093/nar/gkg034
– ident: ref2/cit2
  doi: 10.3109/21678421.2014.887733
– ident: ref27/cit27
  doi: 10.1007/s13361-011-0237-2
– ident: ref51/cit51
  doi: 10.1073/pnas.091062498
– ident: ref42/cit42
  doi: 10.1371/journal.pone.0044401
– ident: ref94/cit94
  doi: 10.1093/hmg/ddp498
– ident: ref14/cit14
  doi: 10.1016/j.neurol.2013.07.019
– ident: ref54/cit54
  doi: 10.1021/ac901335x
– ident: ref22/cit22
  doi: 10.1038/nrneurol.2013.10
– ident: ref46/cit46
  doi: 10.1093/bioinformatics/btp677
– ident: ref77/cit77
  doi: 10.1016/0002-9343(83)90080-3
– ident: ref80/cit80
  doi: 10.1038/nm.2901
– ident: ref35/cit35
  doi: 10.1186/2043-9113-3-1
– ident: ref92/cit92
  doi: 10.1097/NEN.0000000000000086
– ident: ref104/cit104
  doi: 10.1016/j.mcn.2014.06.004
– ident: ref24/cit24
  doi: 10.1038/nrneurol.2011.151
– ident: ref79/cit79
  doi: 10.1016/j.neuroscience.2010.06.057
– ident: ref74/cit74
  doi: 10.1074/jbc.M109.036285
– ident: ref56/cit56
  doi: 10.1101/gr.1239303
– ident: ref59/cit59
  doi: 10.1093/bioinformatics/bti565
– ident: ref23/cit23
  doi: 10.1016/j.jneuroim.2009.09.002
– ident: ref83/cit83
  doi: 10.1016/j.jneuroim.2014.09.005
– ident: ref106/cit106
  doi: 10.1073/pnas.1104977108
– ident: ref90/cit90
  doi: 10.1007/s004010050426
– ident: ref86/cit86
  doi: 10.1016/j.jneuroim.2011.03.011
– ident: ref108/cit108
  doi: 10.1016/j.bbamem.2008.03.013
– volume: 100
  start-page: 84
  year: 2000
  ident: ref4/cit4
  publication-title: Acta Neurol. Belg.
– ident: ref49/cit49
  doi: 10.1111/j.1467-9868.2004.00439.x
– ident: ref95/cit95
  doi: 10.1002/stem.1812
– ident: ref110/cit110
  doi: 10.1002/cbin.10092
– ident: ref99/cit99
  doi: 10.1007/s00401-008-0408-9
– ident: ref85/cit85
  doi: 10.1186/1742-2094-10-119
– ident: ref60/cit60
  doi: 10.1007/978-1-60761-175-2_6
– ident: ref75/cit75
  doi: 10.1371/journal.pone.0013250
– ident: ref50/cit50
  doi: 10.1111/1467-9868.00346
– ident: ref112/cit112
  doi: 10.1007/978-0-387-09595-0_3
– ident: ref67/cit67
  doi: 10.1023/A:1012487302797
– ident: ref11/cit11
  doi: 10.1016/S1474-4422(13)70036-X
– ident: ref26/cit26
  doi: 10.1021/ac0498563
– ident: ref20/cit20
  doi: 10.3109/17482968.2010.541263
– ident: ref66/cit66
  doi: 10.4238/vol7-2gmr426
– ident: ref103/cit103
  doi: 10.1111/jnc.13063
– ident: ref58/cit58
  doi: 10.1093/bioinformatics/btl633
– ident: ref88/cit88
  doi: 10.1007/s12031-010-9467-1
– ident: ref9/cit9
  doi: 10.1111/cge.12117
– ident: ref57/cit57
  doi: 10.1093/bioinformatics/btp101
– ident: ref5/cit5
  doi: 10.1212/WNL.50.1.66
– ident: ref3/cit3
  doi: 10.1016/S0140-6736(10)61156-7
– ident: ref111/cit111
  doi: 10.1110/ps.9.12.2470
– ident: ref28/cit28
  doi: 10.1016/1044-0305(94)80016-2
– ident: ref41/cit41
  doi: 10.1016/j.neulet.2009.10.053
– ident: ref69/cit69
  doi: 10.1371/journal.pone.0087293
– ident: ref70/cit70
  doi: 10.1111/j.1471-4159.2011.07224.x
– ident: ref93/cit93
  doi: 10.1016/j.mcn.2006.03.002
– ident: ref98/cit98
  doi: 10.1038/cddis.2014.25
– ident: ref102/cit102
  doi: 10.1002/ana.22633
– ident: ref105/cit105
  doi: 10.1074/jbc.M212291200
– ident: ref18/cit18
  doi: 10.3109/00207454.2013.848440
– ident: ref12/cit12
  doi: 10.1155/2012/908724
– ident: ref7/cit7
  doi: 10.3109/17482968.2010.550302
– ident: ref36/cit36
  doi: 10.1371/journal.pone.0010980
– ident: ref61/cit61
  doi: 10.1093/bioinformatics/btt019
– ident: ref109/cit109
  doi: 10.1002/cne.22627
– ident: ref72/cit72
  doi: 10.1007/s00401-012-1045-x
– ident: ref55/cit55
  doi: 10.1021/ac901335x
– ident: ref78/cit78
  doi: 10.1016/j.neulet.2009.01.026
– ident: ref97/cit97
  doi: 10.1007/s00441-012-1375-y
– ident: ref16/cit16
  doi: 10.1021/pr049750o
– ident: ref64/cit64
  doi: 10.1145/1656274.1656278
– ident: ref89/cit89
  doi: 10.1159/000107704
– volume: 31
  start-page: 1
  year: 1914
  ident: ref76/cit76
  publication-title: J. Med. Res.
– ident: ref30/cit30
  doi: 10.1038/75556
– ident: ref17/cit17
  doi: 10.1042/BA20080015
– ident: ref29/cit29
  doi: 10.1074/mcp.M500084-MCP200
– ident: ref40/cit40
  doi: 10.1002/pmic.200400871
– reference: 22522477 - Ann Neurol. 2012 May;71(5):614-23
– reference: 18551400 - Genet Mol Res. 2008 Apr 15;7(2):342-56
– reference: 10982861 - Nucleic Acids Res. 2000 Sep 15;28(18):3442-4
– reference: 23700471 - PLoS One. 2013 May 20;8(5):e64314
– reference: 25644224 - J Neurol Neurosurg Psychiatry. 2015 Jun;86(6):667-73
– reference: 10934559 - Acta Neurol Belg. 2000 Jun;100(2):84-90
– reference: 22101323 - Acta Neuropathol. 2011 Dec;122(6):691-702
– reference: 23379621 - Clin Genet. 2013 May;83(5):408-16
– reference: 12538579 - J Biol Chem. 2003 Mar 28;278(13):11351-8
– reference: 20048772 - Acta Neurobiol Exp (Wars). 2009;69(4):564-77
– reference: 25683482 - J Neurochem. 2015 Jun;133(6):879-85
– reference: 22675362 - Int J Cell Biol. 2012;2012:908724
– reference: 23770383 - J Proteomics. 2013 Dec 16;95:55-65
– reference: 9443459 - Neurology. 1998 Jan;50(1):66-72
– reference: 21151566 - PLoS One. 2010 Dec 09;5(12):e15133
– reference: 23505055 - Cell Biol Int. 2013 Jul;37(7):731-6
– reference: 18989684 - Acta Neuropathol. 2009 Jan;117(1):55-62
– reference: 21344998 - Amyotroph Lateral Scler. 2011 May;12(3):199-205
– reference: 10802651 - Nat Genet. 2000 May;25(1):25-9
– reference: 12519996 - Nucleic Acids Res. 2003 Jan 1;31(1):258-61
– reference: 15952730 - J Proteome Res. 2005 May-Jun;4(3):837-45
– reference: 20552007 - PLoS One. 2010 Jun 11;5(6):e10980
– reference: 24085347 - J Neurol. 2013 Nov;260(11):2917-27
– reference: 20007255 - Bioinformatics. 2010 Feb 1;26(3):363-9
– reference: 24475266 - PLoS One. 2014 Jan 27;9(1):e87293
– reference: 14597658 - Genome Res. 2003 Nov;13(11):2498-504
– reference: 19972189 - J Med Res. 1914 Sep;31(1):1-19
– reference: 22922411 - Nat Med. 2012 Sep;18(9):1418-22
– reference: 8834540 - Acta Neuropathol. 1996;91(3):278-83
– reference: 24998676 - Mol Cell Neurosci. 2014 Jul;61:201-10
– reference: 17934327 - Neurodegener Dis. 2007;4(6):431-42
– reference: 4050318 - Acta Neurol Scand. 1985 Jul;72(1):61-4
– reference: 23325622 - Bioinformatics. 2013 Mar 1;29(5):661-3
– reference: 19444952 - Neurosci Lett. 2009 Mar 6;452(1):52-5
– reference: 16677822 - Mol Cell Neurosci. 2006 May-Jun;32(1-2):102-17
– reference: 24625978 - Cell Death Dis. 2014 Mar 13;5:e1119
– reference: 24066851 - Int J Neurosci. 2014 May;124(5):344-9
– reference: 19237447 - Bioinformatics. 2009 Apr 15;25(8):1091-3
– reference: 21501881 - J Neuroimmunol. 2011 Jun;235(1-2):104-9
– reference: 23317455 - J Clin Bioinforma. 2013 Jan 14;3(1):1
– reference: 8302340 - N Engl J Med. 1994 Mar 3;330(9):585-91
– reference: 18420026 - Biochim Biophys Acta. 2008 Jun;1778(6):1429-35
– reference: 19864493 - Hum Mol Genet. 2010 Jan 15;19(2):313-28
– reference: 15979981 - Mol Cell Proteomics. 2005 Oct;4(10):1487-502
– reference: 23415570 - Lancet Neurol. 2013 Mar;12(3):310-22
– reference: 18412540 - Biotechnol Appl Biochem. 2009 Feb;52(Pt 2):159-66
– reference: 17513293 - Mol Cell Proteomics. 2007 Aug;6(8):1354-64
– reference: 12883005 - Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5
– reference: 24548642 - Biol Psychiatry. 2014 May 1;75(9):723-31
– reference: 24011641 - Rev Neurol (Paris). 2013 Oct;169(10):793-8
– reference: 15994189 - Bioinformatics. 2005 Sep 15;21(18):3587-95
– reference: 24226387 - J Am Soc Mass Spectrom. 1994 Nov;5(11):976-89
– reference: 25262158 - J Neuroimmunol. 2014 Nov 15;276(1-2):213-8
– reference: 20948999 - PLoS One. 2010 Oct 11;5(10):e13250
– reference: 21456004 - J Comp Neurol. 2011 Aug 1;519(11):2252-70
– reference: 19710046 - J Neurol Neurosurg Psychiatry. 2010 Apr;81(4):385-90
– reference: 22992788 - Oncol Rep. 2012 Dec;28(6):2233-8
– reference: 8929976 - Neurosci Lett. 1996 Feb 2;204(1-2):53-6
– reference: 22993125 - Acta Neuropathol. 2012 Nov;124(5):717-32
– reference: 21952779 - J Am Soc Mass Spectrom. 2011 Dec;22(12):2199-208
– reference: 15741237 - J Cell Sci. 2005 Mar 15;118(Pt 6):1267-77
– reference: 19597782 - Methods Mol Biol. 2009;563:99-121
– reference: 21300890 - Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3342-7
– reference: 8937538 - Acta Neurol Scand. 1996 Oct;94(4):264-8
– reference: 19850929 - J Biol Chem. 2009 Dec 18;284(51):35597-604
– reference: 21028795 - J Proteome Res. 2010 Dec 3;9(12):6091-100
– reference: 16481598 - Neurology. 2006 Apr 25;66(8):1218-22
– reference: 11309499 - Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21
– reference: 22684992 - Proteomics. 2012 Aug;12(14):2378-90
– reference: 17327847 - Nat Methods. 2007 Mar;4(3):207-14
– reference: 22985433 - Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr;14 (3):199-204
– reference: 6349337 - Am J Med. 1983 Jul 28;75(1B):102-8
– reference: 22437874 - Cell Tissue Res. 2012 Jul;349(1):147-60
– reference: 15540204 - Proteomics. 2004 Dec;4(12):4010-8
– reference: 21126161 - Amyotroph Lateral Scler. 2011 Mar;12(2):140-3
– reference: 24571628 - Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):269-74
– reference: 15253663 - Anal Chem. 2004 Jul 15;76(14):4193-201
– reference: 17720704 - Bioinformatics. 2007 Oct 1;23(19):2507-17
– reference: 19782408 - J Neuroimmunol. 2010 Feb 26;219(1-2):1-7
– reference: 16516157 - Biochem Biophys Res Commun. 2006 Apr 21;342(4):1034-9
– reference: 20600637 - Neuroscience. 2010 Sep 29;170(1):289-97
– reference: 26004848 - J Neurosci Methods. 2015 Aug 15;251:72-82
– reference: 17182697 - Bioinformatics. 2007 Feb 15;23(4):401-7
– reference: 19839595 - Anal Chem. 2009 Dec 1;81(23):9819-23
– reference: 11206068 - Protein Sci. 2000 Dec;9(12):2470-6
– reference: 16313519 - J Neurochem. 2005 Dec;95(5):1461-71
– reference: 19025120 - Adv Exp Med Biol. 2008;632:143-58
– reference: 23124365 - Acta Neuropathol. 2013 Jan;125(1):121-31
– reference: 18925368 - Subcell Biochem. 2008;48:20-30
– reference: 24067070 - J Neuroinflammation. 2013 Sep 26;10 :119
– reference: 21788491 - Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):E440-9
– reference: 18607609 - Acta Neuropathol. 2008 Aug;116(2):205-13
– reference: 23143228 - Acta Neuropathol. 2013 Jan;125(1):95-109
– reference: 25113670 - Stem Cells. 2014 Dec;32(12):3163-72
– reference: 19853641 - Neurosci Lett. 2010 Jan 1;468(1):23-7
– reference: 21989244 - Nat Rev Neurol. 2011 Oct 11;7(11):631-8
– reference: 17124542 - Analyst. 2006 Dec;131(12):1335-41
– reference: 21057983 - J Mol Neurosci. 2011 Mar;43(3):470-7
– reference: 23419373 - Nat Rev Neurol. 2013 Mar;9(3):131-40
– reference: 22970211 - PLoS One. 2012;7(9):e44401
– reference: 21418221 - J Neurochem. 2011 May;117(3):528-37
– reference: 10521349 - Science. 1999 Oct 15;286(5439):531-7
– reference: 24918638 - J Neuropathol Exp Neurol. 2014 Jul;73(7):702-13
– reference: 21296405 - Lancet. 2011 Mar 12;377(9769):942-55
– reference: 15672452 - Proteomics. 2005 Jan;5(1):290-6
SSID ssj0015703
Score 2.444284
Snippet Analysis of the cerebrospinal fluid (CSF) proteome has proven valuable to the study of neurodegenerative disorders. To identify new protein/pathway alterations...
SourceID pubmedcentral
proquest
pubmed
crossref
acs
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 4486
SubjectTerms Adaptor Proteins, Signal Transducing - cerebrospinal fluid
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - isolation & purification
Adult
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - diagnosis
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Amyloid beta-Protein Precursor - cerebrospinal fluid
Amyloid beta-Protein Precursor - genetics
Amyloid beta-Protein Precursor - isolation & purification
amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - cerebrospinal fluid
Amyotrophic Lateral Sclerosis - diagnosis
Amyotrophic Lateral Sclerosis - genetics
Amyotrophic Lateral Sclerosis - pathology
biomarkers
Biomarkers - cerebrospinal fluid
Calcium-Binding Proteins - cerebrospinal fluid
Calcium-Binding Proteins - genetics
Calcium-Binding Proteins - isolation & purification
Case-Control Studies
cell adhesion molecules
Cell Adhesion Molecules - cerebrospinal fluid
Cell Adhesion Molecules - genetics
Cell Adhesion Molecules - isolation & purification
cerebrospinal fluid
Cerebrospinal Fluid Proteins - cerebrospinal fluid
Cerebrospinal Fluid Proteins - genetics
Cerebrospinal Fluid Proteins - isolation & purification
Chromatography, Liquid - methods
Diagnosis, Differential
extracellular matrix
Extracellular Matrix - chemistry
Extracellular Matrix Proteins - cerebrospinal fluid
Extracellular Matrix Proteins - genetics
Extracellular Matrix Proteins - isolation & purification
Humans
Immunoglobulins - cerebrospinal fluid
Immunoglobulins - genetics
Immunoglobulins - isolation & purification
Inflammation
liquid chromatography
Middle Aged
Motor Neuron Disease - cerebrospinal fluid
Motor Neuron Disease - diagnosis
Motor Neuron Disease - genetics
Motor Neuron Disease - pathology
neurons
proteome
Proteome - genetics
Proteome - isolation & purification
Proteome - metabolism
proteomics
Proteomics - methods
Sensitivity and Specificity
Support Vector Machine
support vector machines
Synapses - genetics
Synapses - metabolism
Synaptic Transmission
tandem mass spectrometry
Tandem Mass Spectrometry - methods
Title Label-Free LC–MS/MS Proteomic Analysis of Cerebrospinal Fluid Identifies Protein/Pathway Alterations and Candidate Biomarkers for Amyotrophic Lateral Sclerosis
URI http://dx.doi.org/10.1021/acs.jproteome.5b00804
https://www.ncbi.nlm.nih.gov/pubmed/26401960
https://www.proquest.com/docview/1731783510
https://www.proquest.com/docview/2053889278
https://pubmed.ncbi.nlm.nih.gov/PMC5592736
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lj9MwELaW5QAX3o_ykpE4ISVtnPexRFQr1EUrlZX2FtnxWBtIk1WSCi0n_gO_gL_GL2Emj4qyqhauicd2JuPMN_HMZ8beIEoARKLCAikwQHGczIqVmREXYRzrWaaN7hJkPwZHp96HM__sgE337OALZyqzxv7ckRZUa7B9RRjHu8FuigAXMmGhZLXdNiA6qZ4g1bfIE48lO_u6IZeUNbsu6QrO_Dtd8g__s7jLTsYqnj7t5Iu9aZWdfbtK6vivj3aP3RmwKJ_3xnOfHUD5gN1KxiPgHrKfS6mgsBY1AF8mv77_OF5Nj1f8pO8rz_hIacIrwxOoMb6mY0io00WxyTXvy4ANRuO9EEXhCDm_yks-Lzo-Z7J6LkvNE6qvod8P_F1erSlpqG44Imo-X19WbV1dnON4S0lCBV_hfHGovHnEThfvPyVH1nCmgyURa7WWcb0oMCoO1cx10RQiDQH4WoKUyhA7ntIBGBmazDggYw_Rk6sgCL3M02GkhPuYHZZVCU8Zl_FMQGikFlJ7fuZJHRBbP7ghGFDKnbC3qOB0WJNN2m23CyftLo5aTwetT5g32kCaDezodEhHcZ2YvRW76OlBrhN4PRpYii-TdmdkCdUGpxcilEM87Mz2txH4yYyiWITRhD3pjXI7LCJb4jpC6XDHXLcNiEh8906Zn3eE4hhVIooNnv2Pwp6z24gd_a4sM3jBDtt6Ay8Rn7XqVbcmfwMVNUBd
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZKOZQLb8ryNBInpGzzfhyXiNUCuxXStqK3yI7HaiCbVJtdoXLiP_AL-Gv8EmacZGGLqqpXxzN-ZBx_E3u-Yew1ogRAJOpaIFx0UBwntxKpbeIiTBJl50orc0H2MJwc-x9OgpMdFvaxMNiJBjU15hD_L7uAc0BlXwx3Qb2AYSAJ6vg32E0EJC5Z9iidb04PiFWq5UkNLNqQ-8idy9TQzpQ32zvTf3Dz4q3Jf7ah8R32eTMAc_vk63C9ksP8-wVux-uP8C673SFTPmpN6R7bgeo-20v7hHAP2K-pkFBa4yUAn6a_f_yczQ9mc_6p1VXkvCc44bXmKSzR26akJKR0XK4LxdugYI2-eStEPjkC0G_inI9Kw-5Ma4CLSvGUom3oZwR_W9QLukK0bDjiaz5anNerZX12iu1NBQmVfI79xaaK5iE7Hr87SidWl-HBEoi8Vpb2_DjUMomk7XloGLGCEAIlQAipiStPqhC0iHSuHRCJj1jKkxBGfu6rKJau94jtVnUFjxkXie1CpIVyhfKD3BcqJO5-8CLQIKU3YG9wgrNuhTaZOXx3ncwU9rOedbM-YH5vClnecaVTyo7yKrHhRuysJQu5SuBVb2cZvkw6qxEV1GvsXoTADtGxY19ex8UPaBwnbhQP2H5rm5tmEecS8xFKR1tWu6lAtOLbT6ri1NCLo4-JmDZ8cp0Je8n2JkezaTZ9f_jxKbuFqDIwAZvhM7a7Wq7hOSK3lXxhlukfellIvg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtRAEG1BkIAL-zKsjcQJyRPvy3EwWAEmUaQhUiQOVre7WjF47JE9IxRO_ANfwK_xJVR5ExMURXBtd_XmavcrV9Vrxl4iSgBEorYBwkYDxbIyI5LaJC7CKFJmprRqA2QP_L0j9_2xd9xHVVIuDA6iwZaa1olPu3qldM8wYO1S-eeWv6BawtSTBHfcy-wKue5Iu2fxYvQgELNUx5XqGXQoD9k75zVDp1PWbJ9Of0HOs5GTfxxFyU32aZxEG4HyZbpZy2n27Qy_4__N8ha70SNUPutU6ja7BOUddi0eLoa7y37OhYTCSGoAPo9_ff-xv9jdX_DDrq084wPRCa80j6FGq5suJ6FGk2KTK94lB2u00Tshss0RiH4Vp3xWtCzPtBe4KBWPKeuGfkrw13m1pFCiuuGIs_lseVqt62p1gv3NBQkVfIHjxa7y5h47St5-jPeM_qYHQyACWxvacUNfyyiQpuOggoQKfPCUACGkJs48qXzQItCZtkBELmIqR4IfuJmrglDazn22U1YlPGRcRKYNgRbKFsr1Mlconzj8wQlAg5TOhL3CBU77ndqkrRPettK2cFj1tF_1CXMHdUiznjOdru4oLhKbjmKrjjTkIoEXg66l-DLJZyNKqDY4vAABHqJkyzy_jo0f0jCM7CCcsAedfo7dIt4lBiSUDrY0d6xA9OLbT8r8pKUZR1sTsa3_6F8W7Dm7evgmSefvDj48ZtcRXHpt3qb_hO2s6w08RQC3ls_anfobk4RLQQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Label-Free+LC%E2%80%93MS%2FMS+Proteomic+Analysis+of+Cerebrospinal+Fluid+Identifies+Protein%2FPathway+Alterations+and+Candidate+Biomarkers+for+Amyotrophic+Lateral+Sclerosis&rft.jtitle=Journal+of+proteome+research&rft.au=Collins%2C+Mahlon+A&rft.au=An%2C+Jiyan&rft.au=Hood%2C+Brian+L&rft.au=Conrads%2C+Thomas+P&rft.date=2015-11-06&rft.pub=American+Chemical+Society&rft.issn=1535-3893&rft.eissn=1535-3907&rft.volume=14&rft.issue=11&rft.spage=4486&rft.epage=4501&rft_id=info:doi/10.1021%2Facs.jproteome.5b00804&rft.externalDocID=a448670479
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1535-3893&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1535-3893&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1535-3893&client=summon