Evidence of the simultaneous replications of active viruses in specimens positive for multiple respiratory viruses

• Published in: Microbiology spectrum Vol. 12; no. 1; p. e0192023
• Main Authors: Kawase, Miyuki, Suwa, Reiko, Sugimoto, Satoko, Kakizaki, Masatoshi, Kume, Yohei, Chishiki, Mina, Ono, Takashi, Okabe, Hisao, Norito, Sakurako, Ujike, Makoto, Hosoya, Mitsuaki, Hashimoto, Koichi, Shirato, Kazuya
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 11.01.2024
• Subjects: Child; Clinical Microbiology; co-cultivation; HBTEC-ALI culture; Humans; Pneumonia; Real-Time Polymerase Chain Reaction; real-time RT-PCR; Research Article; Respiratory Tract Infections - diagnosis; respiratory virus; Virus Diseases - diagnosis; Viruses - genetics; co-cultivation; HBTEC-ALI culture; real-time RT-PCR; respiratory virus

Genetic diagnostic assays for the detection of respiratory viruses sometimes show simultaneous multiple infections with low copy numbers. In such cases, the disease is considered caused by a single etiologic agent and others are nonspecific reactions and/or contaminations. Interferon-dependent inter...