Single Amino Acid Substitution in the Receptor Binding Domain of Spike Protein Is Sufficient To Convert the Neutralization Profile between Ethiopian and Middle Eastern Isolates of Middle East Respiratory Coronavirus

• Published in: Microbiology spectrum Vol. 11; no. 2; p. e0459022
• Main Authors: Sugimoto, Satoko, Kakizaki, Masatoshi, Kawase, Miyuki, Kawachi, Kengo, Ujike, Makoto, Kamitani, Wataru, Sentsui, Hiroshi, Shirato, Kazuya
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 06.02.2023
• Subjects: Observation; Virology; Middle East respiratory syndrome (MERS); MERS coronavirus (MERS-CoV); amino acid substitution; neutralization; Ethiopia; dromedary

There have been no reported cases of human Middle East respiratory syndrome (MERS) in Africa, despite the presence of MERS coronavirus (MERS-CoV). Previous studies have shown that recombinant MERS-CoV carrying the S protein of an Ethiopian isolate replicated slower and was more easily neutralized re...