Calcium Signaling Mechanisms Across Kingdoms
Calcium (Ca ) is a unique mineral that serves as both a nutrient and a signal in all eukaryotes. To maintain Ca homeostasis for both nutrition and signaling purposes, the tool kit for Ca transport has expanded across kingdoms of eukaryotes to encode specific Ca signals referred to as Ca signatures....
Saved in:
| Published in | Annual review of cell and developmental biology Vol. 37; p. 311 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
06.10.2021
|
| Subjects | |
| Online Access | Get more information |
Cover
Loading…
| Abstract | Calcium (Ca
) is a unique mineral that serves as both a nutrient and a signal in all eukaryotes. To maintain Ca
homeostasis for both nutrition and signaling purposes, the tool kit for Ca
transport has expanded across kingdoms of eukaryotes to encode specific Ca
signals referred to as Ca
signatures. In parallel, a large array of Ca
-binding proteins has evolved as specific sensors to decode Ca
signatures. By comparing these coding and decoding mechanisms in fungi, animals, and plants, both unified and divergent themes have emerged, and the underlying complexity will challenge researchers for years to come. Considering the scale and breadth of the subject, instead of a literature survey, in this review we focus on a conceptual framework that aims to introduce readers to the principles and mechanisms of Ca
signaling. We finish with several examples of Ca
-signaling pathways, including polarized cell growth, immunity and symbiosis, and systemic signaling, to piece together specific coding and decoding mechanisms in plants versus animals. |
|---|---|
| AbstractList | Calcium (Ca
) is a unique mineral that serves as both a nutrient and a signal in all eukaryotes. To maintain Ca
homeostasis for both nutrition and signaling purposes, the tool kit for Ca
transport has expanded across kingdoms of eukaryotes to encode specific Ca
signals referred to as Ca
signatures. In parallel, a large array of Ca
-binding proteins has evolved as specific sensors to decode Ca
signatures. By comparing these coding and decoding mechanisms in fungi, animals, and plants, both unified and divergent themes have emerged, and the underlying complexity will challenge researchers for years to come. Considering the scale and breadth of the subject, instead of a literature survey, in this review we focus on a conceptual framework that aims to introduce readers to the principles and mechanisms of Ca
signaling. We finish with several examples of Ca
-signaling pathways, including polarized cell growth, immunity and symbiosis, and systemic signaling, to piece together specific coding and decoding mechanisms in plants versus animals. |
| Author | Wang, Chao Luan, Sheng |
| Author_xml | – sequence: 1 givenname: Sheng surname: Luan fullname: Luan, Sheng email: sluan@berkeley.edu organization: Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA; email: sluan@berkeley.edu – sequence: 2 givenname: Chao surname: Wang fullname: Wang, Chao email: sluan@berkeley.edu organization: Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA; email: sluan@berkeley.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34375534$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1jstKxDAUQIMozkN_QbpxZzTJzU0my6H4whEX6npI0tsx0qZDYwX_XkFdHTiLw1mwwzxkYuxciksptbnyOU8jffJIXRfSwKUSSjouAJUUB2wuEQRfOYcztijlXQjhAPCYzUCDRQQ9Zxe172Ka-uo57bLvUt5VjxTffE6lL9U6jkMp1cOPboa-nLCj1neFTv-4ZK831y_1Hd883d7X6w33KPCDgwKwxgvfkF-Z1mhFmrAlWrVatCQbikaiEsGiBxfA2UCSgrEYJEYr1ZKd_Xb3U-ip2e7H1Pvxa_u_rb4B31VJGQ |
| CitedBy_id | crossref_primary_10_3389_fendo_2023_1193556 crossref_primary_10_3390_agronomy14081646 crossref_primary_10_1093_plphys_kiae365 crossref_primary_10_1007_s11427_022_2330_4 crossref_primary_10_1111_tpj_17179 crossref_primary_10_1016_j_molp_2023_04_002 crossref_primary_10_1111_jipb_13812 crossref_primary_10_1016_j_stress_2024_100551 crossref_primary_10_3390_ijms25189813 crossref_primary_10_3389_fpls_2023_1093472 crossref_primary_10_1016_j_aquaculture_2024_742039 crossref_primary_10_1093_plcell_koac209 crossref_primary_10_1093_plphys_kiad433 crossref_primary_10_3390_cimb47030205 crossref_primary_10_1016_j_tibs_2023_06_002 crossref_primary_10_1038_s41586_022_04923_7 crossref_primary_10_3389_fpls_2022_984909 crossref_primary_10_3390_agronomy14102421 crossref_primary_10_1016_j_jenvman_2023_117826 crossref_primary_10_1016_j_xplc_2023_100678 crossref_primary_10_1016_j_ceb_2022_102080 crossref_primary_10_1093_pcp_pcad142 crossref_primary_10_1016_j_cell_2024_03_045 crossref_primary_10_1093_plcell_koae245 crossref_primary_10_3389_fpls_2022_1019505 crossref_primary_10_1007_s00438_024_02220_8 crossref_primary_10_1016_j_scib_2025_02_010 crossref_primary_10_3390_plants13162238 crossref_primary_10_4236_aim_2022_129038 crossref_primary_10_1126_sciadv_ado5545 crossref_primary_10_1088_1478_3975_acf7a1 crossref_primary_10_1111_pce_14686 crossref_primary_10_3390_ijms24010598 crossref_primary_10_1094_MPMI_05_23_0073_HH crossref_primary_10_3389_fpls_2023_1255805 crossref_primary_10_1016_j_ceca_2021_102519 crossref_primary_10_1002_mco2_283 crossref_primary_10_1038_s41467_024_53648_w crossref_primary_10_1042_EBC20220067 crossref_primary_10_1093_plcell_koac033 crossref_primary_10_3390_ijms23031027 crossref_primary_10_1093_jxb_erad442 crossref_primary_10_7554_eLife_80336 crossref_primary_10_1093_pcp_pcae127 crossref_primary_10_1126_sciadv_adr7434 crossref_primary_10_1007_s00203_022_03095_2 crossref_primary_10_1021_acs_jpclett_4c00693 crossref_primary_10_1016_j_jhazmat_2024_134682 crossref_primary_10_1113_JP284247 crossref_primary_10_1016_j_molp_2021_11_012 crossref_primary_10_3390_ijms23105826 crossref_primary_10_1016_j_mocell_2024_100104 crossref_primary_10_3389_fpls_2022_1004406 crossref_primary_10_1111_nph_20295 crossref_primary_10_1186_s13075_023_03093_9 crossref_primary_10_1038_s41467_022_35373_4 crossref_primary_10_1093_plphys_kiae054 crossref_primary_10_1016_j_pbi_2022_102251 crossref_primary_10_1016_j_mib_2023_102267 crossref_primary_10_1093_jxb_erac105 crossref_primary_10_1186_s12864_024_10264_8 crossref_primary_10_1016_j_envexpbot_2023_105277 crossref_primary_10_1038_s41477_023_01578_8 crossref_primary_10_1093_plphys_kiae613 crossref_primary_10_3390_ijms222011000 crossref_primary_10_1085_jgp_202213104 crossref_primary_10_1186_s42483_023_00215_8 crossref_primary_10_1093_plcell_koae279 crossref_primary_10_1111_nph_20311 crossref_primary_10_1113_JP279510 crossref_primary_10_1016_j_cj_2024_02_007 crossref_primary_10_1016_j_fgb_2023_103842 crossref_primary_10_1038_s41586_024_07100_0 crossref_primary_10_1111_jipb_13613 crossref_primary_10_3390_jof8070750 crossref_primary_10_1016_j_tig_2023_07_001 crossref_primary_10_1016_j_scib_2024_09_031 crossref_primary_10_1021_acs_jpcb_4c08416 crossref_primary_10_3390_ijms24044054 crossref_primary_10_1080_15592324_2023_2204284 crossref_primary_10_1093_plcell_koae153 crossref_primary_10_1094_MPMI_12_23_0208_R crossref_primary_10_1016_j_ncrops_2024_100057 crossref_primary_10_3390_ijms25136932 crossref_primary_10_1016_j_scib_2023_05_008 crossref_primary_10_1111_nph_19795 crossref_primary_10_1111_nph_19433 crossref_primary_10_1111_nph_19712 crossref_primary_10_3389_fimmu_2025_1550699 crossref_primary_10_2139_ssrn_4103913 crossref_primary_10_1016_j_sajb_2024_04_047 crossref_primary_10_1007_s44154_024_00170_0 crossref_primary_10_1038_s41467_023_41928_w crossref_primary_10_1186_s12870_023_04713_x crossref_primary_10_3390_cells13060468 crossref_primary_10_1038_s41422_022_00754_3 crossref_primary_10_1111_nph_18626 crossref_primary_10_3389_fpls_2023_1276649 crossref_primary_10_1016_j_pbi_2023_102485 crossref_primary_10_1017_qpb_2025_6 crossref_primary_10_1093_plphys_kiad171 crossref_primary_10_1016_j_cellsig_2023_110846 crossref_primary_10_1007_s11105_021_01330_6 crossref_primary_10_1016_j_neuint_2023_105634 crossref_primary_10_1007_s44154_024_00188_4 crossref_primary_10_1111_nph_18698 crossref_primary_10_1016_j_molp_2022_11_011 crossref_primary_10_1016_j_aquaculture_2022_738344 crossref_primary_10_1038_s41477_024_01865_y crossref_primary_10_3390_ijms242015059 crossref_primary_10_3390_molecules29235627 crossref_primary_10_1093_hr_uhad261 crossref_primary_10_1016_j_ygeno_2022_110398 crossref_primary_10_1111_jipb_13754 crossref_primary_10_1007_s10725_024_01176_4 crossref_primary_10_1093_plphys_kiad337 crossref_primary_10_32604_biocell_2024_048076 crossref_primary_10_1111_nph_18044 crossref_primary_10_3390_ijms23136973 crossref_primary_10_1016_j_cej_2023_144985 crossref_primary_10_3389_fpls_2024_1436651 crossref_primary_10_1007_s12088_023_01107_3 crossref_primary_10_1016_j_neuroscience_2025_02_013 crossref_primary_10_1016_j_jclepro_2024_141662 crossref_primary_10_3390_ijms25010001 crossref_primary_10_3390_ijms25105310 crossref_primary_10_1093_plcell_koac241 crossref_primary_10_3390_ijms242316812 crossref_primary_10_1016_j_stress_2023_100328 crossref_primary_10_1007_s12298_023_01405_6 crossref_primary_10_1016_j_plantsci_2024_112239 crossref_primary_10_1139_gen_2024_0053 crossref_primary_10_1016_j_molp_2023_09_007 crossref_primary_10_1111_nph_18968 crossref_primary_10_1093_plphys_kiad047 crossref_primary_10_1016_j_plaphy_2022_03_032 |
| ContentType | Journal Article |
| DBID | NPM |
| DOI | 10.1146/annurev-cellbio-120219-035210 |
| DatabaseName | PubMed |
| DatabaseTitle | PubMed |
| DatabaseTitleList | PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1530-8995 |
| ExternalDocumentID | 34375534 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: R01 GM138401 |
| GroupedDBID | --- -QD -QH -~X 0R~ 1KX 23M 36B 39C 4.4 51A 5FA 5FB 5FC 5FD 5FE 5FF 5GY 5RE 7A. 85S AABJL AAGWO AALHT AALUV AAOHI AAQMF AARJV AAWJP AAXSQ AAYIS ABDOG ABGRM ABIPL ABJNI ABKGM ABPPZ ABVYV ABZNY ACAHA ACDVT ACGFS ACGOD ACJYF ACKHT ACMXS ACNCT ACPHO ACPRK ACQCJ ACQLW ACRLM ACSOE ADANS ADHEY ADIYS ADLON ADNJN ADSVE AEAIQ AEKBM AENEX AEPIK AFCZG AFERR AFKDQ AFKEJ AFONB AGBCJ AHIXL AHKZM AHMBA AHVNO AICBU AIDEK AIJFW AIZOL AJAAW ALAFQ ALIPV ALMA_UNASSIGNED_HOLDINGS AMTJG AOUBY AQQLW ATAUN B9D B9E B9F B9G B9H B9L B9N BCFVH BJPMW BMYRD CS3 EBS EMB F-Q F-S F-V F-X F-Y F-Z F5P FIWKU FIXEU FMZAJ FQMFW FT0 FU. FUEKT FXG GJQJI GLOEX GNDDA GOAVI GQXMV H13 HZ~ J1V M22 NPM O9- P2P RAR RAV RNS X7N XSW YSK YZZ ZYWBE |
| ID | FETCH-LOGICAL-a505t-323376a0adea86f642e4e5fee8f40fe1dec61520b75a39b397be1eb675b15c712 |
| IngestDate | Mon Jul 21 06:08:11 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | protein kinases polarized cell growth innate immunity calcium channels systemic signaling calcium-binding proteins |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-a505t-323376a0adea86f642e4e5fee8f40fe1dec61520b75a39b397be1eb675b15c712 |
| OpenAccessLink | https://www.annualreviews.org/doi/pdf/10.1146/annurev-cellbio-120219-035210 |
| PMID | 34375534 |
| ParticipantIDs | pubmed_primary_34375534 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-10-06 |
| PublicationDateYYYYMMDD | 2021-10-06 |
| PublicationDate_xml | – month: 10 year: 2021 text: 2021-10-06 day: 06 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Annual review of cell and developmental biology |
| PublicationTitleAlternate | Annu Rev Cell Dev Biol |
| PublicationYear | 2021 |
| SSID | ssj0009335 |
| Score | 2.6593986 |
| SecondaryResourceType | review_article |
| Snippet | Calcium (Ca
) is a unique mineral that serves as both a nutrient and a signal in all eukaryotes. To maintain Ca
homeostasis for both nutrition and signaling... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 311 |
| Title | Calcium Signaling Mechanisms Across Kingdoms |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34375534 |
| Volume | 37 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NS8MwFA9OcXgRv7-lBz3NaLska3scQxFBL26w20jaFzdwH-B20L_elyZdy9ShXkJpSpr2177-3mve7xFy4fMUhGzEVMdpSJGBJzSSHCjoJPTN31cRmWzkx6fGfYc_dEW3KPyXZZdM1XXy8W1eyX9QxX2Iq8mS_QOy80FxB24jvtgiwtj-CuOWfE0Gs2HtefBi-DQ6_Y9gMnkHb8O3WjP7ANZM0ZJ07DTJC9XkWSbon6etmPB99hshLdYQ4QFOoWm-aGfmoqV9cN-7LBJvrUWrL8flEELdrmFzAtS52fMpel6ibBetGIszbMyaxK8Gt6w0TM1scWo0MGeJqdFatYtWS2BMhhkajLNQCBvIXN67oIedd1VIBT0DU-rUxGdymWXGRJVcupndLJ3XBqnmYy34FBm3aG-RTecUeE2L8DZZgdEOWbdlQt93yZXD2Zvj7BU4exZnL8d5j3Tubtute-qqXFCJ7HNKWZ2hkZe-TEFGDY3-IHAQGiDS3NcQpJAg66z7KhSSxQr5o4IAFDp6KhBJGNT3yepoPIJD4vEkDJGCS5UiaYuUUFxpdAdZHMW-ljw8Igf2MnsTK2XSy2_A8Y89J2SjeGROyZrGdwfOkIhN1Xl27z8Bn2cxcQ |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Calcium+Signaling+Mechanisms+Across+Kingdoms&rft.jtitle=Annual+review+of+cell+and+developmental+biology&rft.au=Luan%2C+Sheng&rft.au=Wang%2C+Chao&rft.date=2021-10-06&rft.eissn=1530-8995&rft.volume=37&rft.spage=311&rft_id=info:doi/10.1146%2Fannurev-cellbio-120219-035210&rft_id=info%3Apmid%2F34375534&rft_id=info%3Apmid%2F34375534&rft.externalDocID=34375534 |