The Shigella flexneri virulence factor apyrase is released inside eukaryotic cells to hijack host cell fate

• Published in: Microbiology spectrum Vol. 11; no. 6; p. e0077523
• Main Authors: Perruzza, Lisa, Zagaglia, Carlo, Vitiello, Laura, Sarshar, Meysam, Strati, Francesco, Pasqua, Martina, Grassi, Fabio, Nicoletti, Mauro, Palamara, Anna Teresa, Ambrosi, Cecilia, Scribano, Daniela
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 12.12.2023
• Subjects: apyrase; ATP; Clinical Microbiology; host cell survival; inflammation; pyroptosis; Research Article; Shigella flexneri; pyroptosis; Shigella flexneri; apyrase; host cell survival; inflammation; ATP

Intestinal epithelial cells represent the first line of defense from invading enteric pathogens. During the course of infection, pro-inflammatory programmed cell death is an effective way to eliminate invading microbes and to create a localized inflammatory environment. On the other hand, pathogens...