Limited Variation between SARS-CoV-2-Infected Individuals in Domain Specificity and Relative Potency of the Antibody Response against the Spike Glycoprotein

• Published in: Microbiology spectrum Vol. 10; no. 1; p. e0267621
• Main Authors: Van Ert, Hanora A., Bohan, Dana W., Rogers, Kai, Fili, Mohammad, Rojas Chávez, Roberth A., Qing, Enya, Han, Changze, Dempewolf, Spencer, Hu, Guiping, Schwery, Nathan, Sevcik, Kristina, Ruggio, Natalie, Boyt, Devlin, Pentella, Michael A., Gallagher, Tom, Jackson, J. Brooks, Merrill, Anna E., Knudson, C. Michael, Brown, Grant D., Maury, Wendy, Haim, Hillel
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 23.02.2022
• Subjects: Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody Formation; antibody neutralization; convalescent-phase plasma; COVID-19; COVID-19 - blood; COVID-19 - immunology; COVID-19 - virology; Enzyme-Linked Immunosorbent Assay; Host-Microbial Interactions; Humans; immunoassay; Neutralization Tests; Protein Domains; Research Article; SARS-CoV-2; SARS-CoV-2 - chemistry; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; spike protein; COVID-19; SARS-CoV-2; spike glycoprotein; receptor-binding domain; spike protein; antibody neutralization; convalescent-phase plasma; neutralizing antibodies; N-terminal domain; immunoglobulins; adaptive immunity; immunoassay

Infection by SARS-CoV-2 elicits antibodies against various domains of the spike protein, including the RBD and NTD of subunit S1 and against subunit S2. The antibody responses of different infected individuals exhibit different efficacies to inactivate (neutralize) the virus. The spike protein of se...