Unique Gut Microbiome in HIV Patients on Antiretroviral Therapy (ART) Suggests Association with Chronic Inflammation

• Published in: Microbiology spectrum Vol. 9; no. 1; p. e0070821
• Main Authors: Ishizaka, Aya, Koga, Michiko, Mizutani, Taketoshi, Parbie, Prince Kofi, Prawisuda, Diki, Yusa, Nozomi, Sedohara, Ayako, Kikuchi, Tadashi, Ikeuchi, Kazuhiko, Adachi, Eisuke, Koibuchi, Tomohiko, Furukawa, Yoichi, Tojo, Arinobu, Imoto, Seiya, Suzuki, Yutaka, Tsutsumi, Takeya, Kiyono, Hiroshi, Matano, Tetsuro, Yotsuyanagi, Hiroshi
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 03.09.2021
• Subjects: Adult; Anti-HIV Agents - adverse effects; Anti-HIV Agents - therapeutic use; Bacteria - classification; Bacteria - drug effects; Bacteria - genetics; Bacteria - isolation & purification; CD4-Positive T-Lymphocytes - immunology; Chronic Disease - therapy; dysbiosis; Dysbiosis - etiology; Dysbiosis - microbiology; Female; Gastrointestinal Microbiome - drug effects; Gastrointestinal Tract - microbiology; HIV; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - microbiology; human immunodeficiency virus; Humans; inflammation; Male; microbiome; microbiota; Middle Aged; Research Article; Virology; microbiota; human immunodeficiency virus; HIV; inflammation; microbiome; dysbiosis

Chronic inflammation is a hallmark of HIV infection and is associated with the development and progression of age-related comorbidities. Although the gastrointestinal tract is a major site of HIV replication and CD4 + T-cell depletion, the role of HIV-associated imbalance of gut microbiome in chroni...