EDTA and Taurolidine Affect Pseudomonas aeruginosa Virulence In Vitro —Impairment of Secretory Profile and Biofilm Production onto Peritoneal Dialysis Catheters

• Published in: Microbiology spectrum Vol. 9; no. 3; p. e0104721
• Main Authors: Colombari, Bruna, Alfano, Gaetano, Gamberini, Christian, Cappelli, Gianni, Blasi, Elisabetta
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 22.12.2021
• Subjects: Anti-Bacterial Agents - pharmacology; Bacterial Load - drug effects; biofilm; Biofilms - drug effects; Biofilms - growth & development; Catheter-Related Infections - drug therapy; Catheter-Related Infections - microbiology; Catheter-Related Infections - prevention & control; Catheters, Indwelling - microbiology; Clinical Microbiology; Drug Therapy, Combination; Edetic Acid - pharmacology; Humans; lock solutions; Peritoneal Dialysis - adverse effects; peritoneal dialysis catheters; Peritonitis - drug therapy; Peritonitis - microbiology; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - growth & development; Pseudomonas aeruginosa - pathogenicity; Pseudomonas Infections - drug therapy; Pseudomonas Infections - prevention & control; Research Article; Taurine - analogs & derivatives; Taurine - pharmacology; Thiadiazines - pharmacology; Virulence - drug effects; lock solutions; peritoneal dialysis catheters; Pseudomonas aeruginosa; biofilm

An in vitro model allows studies of the mechanisms by which the lock solutions exert their antimicrobial effects on catheter-associated biofilm, thus providing a better understanding of the management of devise-associated infections. Peritoneal catheter-associated biofilm infection is reported to be...