O -Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli -Containing Vacuoles in Macrophage-Like Cells

• Published in: Microbiology spectrum Vol. 9; no. 3; p. e0039921
• Main Authors: Yang, Jinghua, Ma, Wei, Wu, Yuanyuan, Zhou, Hui, Song, Siyu, Cao, Yuqi, Wang, Chengxu, Liu, Xiangyuan, Ren, Jinwei, Duan, Jinyou, Pei, Zhichao, Jin, Cheng
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 22.12.2021
• Subjects: Acetylation; adherence; Animals; Bacterial Capsules - immunology; Bacteriology; capsular polysialic acid; Escherichia coli - genetics; Escherichia coli - immunology; Escherichia coli Infections - genetics; Escherichia coli Infections - immunology; Escherichia coli Infections - microbiology; Escherichia coli K1; Host-Pathogen Interactions; Humans; Immune Evasion; Immunity, Innate; invasion; Lysosomes - immunology; Lysosomes - microbiology; Male; Mice; O-acetylation; Research Article; Sialic Acid Binding Immunoglobulin-like Lectins - genetics; Sialic Acid Binding Immunoglobulin-like Lectins - immunology; Sialic Acids - immunology; Siglecs; Vacuoles - immunology; Vacuoles - microbiology; pathogenesis; invasion; capsular polysialic acid; adherence; interaction; O-acetylation; intracellular trafficking; Siglecs; macrophage-like cells; Escherichia coli K1

Escherichia coli K1 is a leading cause of neonatal meningitis. The mortality and morbidity of this disease remain significantly high despite antibiotic therapy. Escherichia coli K1 causes bacteremia and meningitis in human neonates. The K1 capsule, an α2,8-linked polysialic acid (PSA) homopolymer, i...