Emergence and Genomic Characterization of Neisseria gonorrhoeae Isolates with High Levels of Ceftriaxone and Azithromycin Resistance in Guangdong, China, from 2016 to 2019

• Published in: Microbiology spectrum Vol. 10; no. 6; p. e0157022
• Main Authors: Lin, Xiaomian, Chen, Wentao, Yu, Yuqi, Lan, Yinyuan, Xie, Qinghui, Liao, Yiwen, Wu, Xingzhong, Tang, Sanmei, Qin, Xiaolin, Zheng, Heping
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 21.12.2022
• Subjects: 23S rRNA; A2735; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antimicrobial Chemotherapy; Azithromycin - pharmacology; Azithromycin - therapeutic use; Ceftriaxone - pharmacology; Ceftriaxone - therapeutic use; China - epidemiology; Drug Resistance, Bacterial - genetics; dual resistance; genome analysis; Genomics; Gonorrhea - drug therapy; Gonorrhea - epidemiology; Humans; Microbial Sensitivity Tests; N. gonorrhoeae; Neisseria gonorrhoeae - genetics; penA-60.001; Phylogeny; Research Article; China; 23S rRNA; A2735; FC428; F89; genome analysis; penA-60.001; dual resistance; N. gonorrhoeae

Here, we report five sporadic dual-resistant isolates, including FC428-related ceftriaxone-resistant clones with MICs of ≥0.5 mg/L and high-level azithromycin resistance with MICs of ≥1,024 mg/L. This study highlights that dual-resistant clones with the same evolutionary origin as FC428, A2735, and...