Human Brain Metabolic Response to Caffeine and the Effects of Tolerance

• Published in: The American journal of psychiatry Vol. 156; no. 2; pp. 229 - 237
• Main Authors: Dager, Stephen R., Layton, Matthew E., Strauss, Wayne, Richards, Todd L., Heide, Aaron, Friedman, Seth D., Artru, Alan A., Hayes, Cecil E., Posse, Stefan
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.02.1999; American Psychiatric Association
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Anxiety - chemically induced; Arousal - drug effects; Arousal - physiology; Aspartic Acid - analogs & derivatives; Aspartic Acid - metabolism; Biological and medical sciences; Brain; Brain - blood supply; Brain - drug effects; Brain - metabolism; Caffeine; Caffeine - adverse effects; Caffeine - pharmacokinetics; Caffeine - pharmacology; Citrates - adverse effects; Citrates - pharmacokinetics; Citrates - pharmacology; Coffee; Drug Combinations; Echo-Planar Imaging - methods; Factors; Female; Glycolysis - drug effects; Humans; Lactates - metabolism; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy - methods; Male; Medical sciences; Metabolism; Miscellaneous; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Regional Blood Flow - drug effects; Responses; Tolerance; Human; Abuse; Stimulative beverage; Central nervous system; Tolerance; Drinking; Xanthine derivatives; Metabolism; Caffeine; Brain (vertebrata)

OBJECTIVE: Since there is limited information concerning caffeine's metabolic effects on the human brain, the authors applied a rapid proton echo-planar spectroscopic imaging technique to dynamically measure regional brain metabolic responses to caffeine ingestion. They specifically measured ch...