SARS-CoV-2 N Gene G29195T Point Mutation May Affect Diagnostic Reverse Transcription-PCR Detection

• Published in: Microbiology spectrum Vol. 10; no. 1; p. e0222321
• Main Authors: Ko, Karrie K K, Abdul Rahman, Nurdyana Binte, Tan, Shireen Yan Ling, Chan, Kenneth X L, Goh, Sui Sin, Sim, James Heng Chiak, Lim, Kun Lee, Tan, Wan Loo, Chan, Kian Sing, Oon, Lynette L E, Nagarajan, Niranjan, Suphavilai, Chayaporn
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 23.02.2022
• Subjects: Clinical Microbiology; diagnostic escape; G29195T; N gene; Observation; SARS-CoV-2; G29195T; SARS-CoV-2; N gene; diagnostic escape

Rapid onsite whole-genome sequencing of two suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) N gene diagnostic escape samples revealed a previously unreported N gene point mutation at genome position 29195. Because the G29195T mutation occurs within a region probed by a commonl...