Age-related impairments on one hippocampal-dependent task predict impairments on a subsequent hippocampal-dependent task

• Published in: Behavioral neuroscience Vol. 128; no. 6; p. 676
• Main Authors: Curlik, Daniel M, Weiss, Craig, Nicholson, Daniel A, Disterhoft, John F
• Format: Journal Article
• Language: English
• Published: United States 01.12.2014
• Subjects: Age Factors; Aging; Analysis of Variance; Animals; Blinking - physiology; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Conditioning, Classical; Hippocampus - physiology; Learning Disorders - pathology; Learning Disorders - physiopathology; Male; Maze Learning; Memory Disorders - pathology; Memory Disorders - physiopathology; Predictive Value of Tests; Rats; Rats, Inbred F344

Age-related cognitive impairments are particularly prevalent in forms of learning that require a functionally intact hippocampal formation, such as spatial and declarative learning. However, there is notable heterogeneity in the cognitive abilities of aged subjects. To date, few studies have determi...