Potential Role of Sox9 in Patterning Tracheal Cartilage Ring Formation in an Embryonic Mouse Model

• Published in: Archives of otolaryngology--head & neck surgery Vol. 130; no. 6; pp. 732 - 736
• Main Authors: Elluru, Ravindhra G, Whitsett, Jeffrey A
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Medical Association 01.06.2004
• Subjects: Animals; Biological and medical sciences; Chondrogenesis - physiology; Collagen Type II - genetics; Gene Expression Regulation, Developmental; High Mobility Group Proteins - genetics; In Situ Hybridization; Lung - embryology; Medical sciences; Mice; Models, Animal; Otorhinolaryngology. Stomatology; SOX9 Transcription Factor; Trachea - embryology; Transcription Factors - genetics; Cartilage; Embryonic development; Vertebrata; Mammalia; Mouse; Animal; Rodentia; Models; ENT; Transcription factor; Trachea

OBJECTIVE To identify genes expressed early in the formation of the mouse trachea that control patterning of tracheal cartilaginous rings. DESIGN The mouse larynx and trachea begin as an outpouching from the ventral foregut endoderm at embryonic day (E) 9. Digoxigenin-labeled RNA probes to putative...