Interactions between DNA and Poly(amido amine) Dendrimers on Silica Surfaces

• Published in: Langmuir Vol. 26; no. 11; pp. 8625 - 8635
• Main Authors: Ainalem, Marie-Louise, Campbell, Richard A, Nylander, Tommy
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.06.2010
• Subjects: Biological Interfaces: Biocolloids, Biomolecular and Biomimetic Materials; Chemical Sciences; Chemistry; Colloidal state and disperse state; Dendrimers - chemistry; DNA - chemistry; Exact sciences and technology; Fysikalisk kemi; Fysikalisk kemi (Här ingår: Yt- och kolloidkemi); General and physical chemistry; Kemi; Natural Sciences; Naturvetenskap; Physical Chemistry; Physical Chemistry (including Surface- and Colloid Chemistry); Silicon Dioxide - chemistry; Surface physical chemistry; Monolayer; Binary compound; Deformation; In situ; Neutrons; Potential; Silica; Solid; Amine; Reflectometry; Electrostatic repulsion; Binding; Surface charge; Stability; Multilayer; Branched polymer; Rinsing; Complexes; Bilayer; Ellipsometry; Charge density; Electrostatic attraction; DNA; Morphology; Interface; Dendritic structure
• ISSN: 0743-7463; 1520-5827; 1520-5827
• DOI: 10.1021/la9047177

This study increases the understanding at a molecular level of the interactions between DNA and poly(amido amine) (PAMAM) dendrimers on solid surfaces, which is a subject of potential interest in applications such as gene therapy. We have used in situ null ellipsometry and neutron reflectometry to s...