Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons

• Published in: JAMA : the journal of the American Medical Association Vol. 317; no. 22; pp. 2305 - 2316
• Main Authors: Donohue, Michael C, Sperling, Reisa A, Petersen, Ronald, Sun, Chung-Kai, Weiner, Michael W, Aisen, Paul S
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 13.06.2017
• Subjects: Age; Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - diagnostic imaging; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - metabolism; Assaying; Biomarkers - cerebrospinal fluid; Boxes; Brain; Brain - diagnostic imaging; Brain - metabolism; Canada; Cerebrospinal fluid; Clinical significance; Cognition; Cognitive ability; Dementia disorders; Emission; Female; Follow-Up Studies; Humans; Male; Medical imaging; Memory; Mental Recall; Mental Status Schedule; Neurodegenerative diseases; Neuroimaging; Neurology; Positron emission; Positron emission tomography; Positron Emission Tomography Computed Tomography; Recall; Risk; Statistical analysis; Time Factors; Tomography; United States; β-Amyloid
• ISSN: 0098-7484; 1538-3598; 1538-3598
• DOI: 10.1001/jama.2017.6669

IMPORTANCE: Among cognitively normal individuals, elevated brain amyloid (defined by cerebrospinal fluid assays or positron emission tomography regional summaries) can be related to risk for later Alzheimer-related cognitive decline. OBJECTIVE: To characterize and quantify the risk for Alzheimer-rel...