Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients
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Published in | Antimicrobial Agents and Chemotherapy Vol. 40; no. 9; pp. 1995 - 1997 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Washington, DC
American Society for Microbiology
01.09.1996
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AbstractList | In a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for their ability to prevent catheter infection in 254 intensive care unit patients. The chlorhexidine coating was not efficacious, and a rabbit model demonstrated that reduction of chlorhexidine activity by gamma radiation sterilization was the likely explanation for the failure. Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC |
Author | J Hu R J Sherertz W Carruth D Bowton J Pepe P Scuderi T Burke B Satishchandra L Gentry I I Raad S O Heard J Dupuis A Mosenthal |
AuthorAffiliation | Section on Infectious Diseases, Bowman Gray School of Medicine, Winston-Salem, North Carolina, USA |
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Keywords | Human Infection Prevention Gamma radiation Antiseptic Sterilization Catheter Intensive care unit |
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References | 2802545 - Antimicrob Agents Chemother. 1989 Aug;33(8):1174-8 2405016 - J Clin Microbiol. 1990 Jan;28(1):76-82 3046351 - Am J Med. 1988 Sep;85(3):307-14 7734001 - J Infect Dis. 1993 Jan;167(1):98-106 2492354 - JAMA. 1989 Feb 10;261(6):878-83 6993589 - J Infect Dis. 1980 Jun;141(6):781-6 8089070 - J Antimicrob Chemother. 1994 May;33(5):969-78 8207039 - J Biomed Mater Res. 1994 Feb;28(2):259-67 323710 - N Engl J Med. 1977 Jun 9;296(23):1305-9 |
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StumbleUpon... In a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for... |
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SubjectTerms | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiseptics Bacteremia - microbiology Bacteremia - prevention & control Biological and medical sciences Catheterization Catheterization - adverse effects Catheterization - instrumentation Chlorhexidine Chlorhexidine - pharmacology Clinical Trial Critical Care Cross Infection Cross Infection - blood Cross Infection - microbiology Cross Infection - prevention & control Disinfectants Disinfectants - pharmacology Double-Blind Method Gamma Rays Humans Medical sciences Multicenter Study Pharmacology. Drug treatments Randomized Controlled Trial Research Support, Non-U.S. Gov't Sterilization Sterilization - methods |
Title | Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients |
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