Antimicrobial resistance in human oral and intestinal anaerobic microfloras

Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commerc...

Full description

Saved in:
Bibliographic Details
Published inAntimicrobial Agents and Chemotherapy Vol. 37; no. 8; pp. 1665 - 1669
Main Authors STARK, C. A, EDLUND, C, SJÖSTEDT, S, KRISTENSEN, G, NORD, C. E
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.08.1993
Subjects
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Antineoplastic agents
Bacteria, Anaerobic
Bacteria, Anaerobic - drug effects
Bacteroides fragilis - drug effects
Biological and medical sciences
Chemotherapy
Drug Resistance, Microbial
Feces - microbiology
Female
Humans
Intestines
Intestines - microbiology
Length of Stay
Male
Medical sciences
Middle Aged
Mouth
Mouth - microbiology
Pharmacology. Drug treatments
Research Article
Saliva - microbiology
Human
Gut
Microflora
Hospitalization
Penicillin derivatives
Resistance
Oral cavity
Antibiotic
Cephalosporin derivatives
Anaerobe
Bacteria
Ambulatory
Feces
Antibacterial agent
Saliva
Comparative study
Online AccessGet full text

Cover

Abstract Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
AbstractList In the present study we determined the resistance patterns of anaerobic bacteria from human saliva and stool specimens and investigated whether there were significant differences in resistance between outpatients and hospitalized patients, regardless of whether they had received antimicrobial agents. No bacterial strains resistant to ampicillin, piperacillin, cefoxitin, cefuroxime, imipenem, clindamycin, doxycycline, chloramphenicol, or metronidazole were isolated from the saliva samples. However, resistance to ampicillin, cefoxitin, and cefuroxime was found in strains from 70% of the fecal samples (mainly Bacteroides thetaiotaomicron, Clostridium innocuum, and Bacteroides ovatus). Resistance to both ampicillin and cefuroxime was frequently found in 19% of the isolated strains (mainly B. thetaiotaomicron, B. ovatus, and Bacteroides vulgatus). No strains that were resistant to imipenem, chloramphenicol, or metronidazole were found. Hospitalization and/or intake of antimicrobial agents was associated with an increase in the relative number of resistant anaerobic intestinal bacteria. The percentage of resistant anaerobic strains encountered, compared with the total number of anaerobic bacteria in the normal fecal microflora, was between 5.2 and 14.8%, with the lower value associated with the outpatient group. Two-thirds of the resistant strains from this group had a relative frequency of less than 1% of the total anaerobic flora, while one-third of the strains were present at a level of greater than 1%; for the hospitalized patients, two-thirds of the strains were present at a level of greater than 1%, and one-third of the strains were present at a level of less than 1% (P < 0.001). Patients who had received antimicrobial agents for 6 days or more (n=20) had an average of 1.6 resistant anaerobic strains each, while patients treated for 3 to 5 days (n = 30) had a mean number of 0.87 resistant strains each ( P < 0.05).
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
In the present study we determined the resistance patterns of anaerobic bacteria from human saliva and stool specimens and investigated whether there were significant differences in resistance between outpatients and hospitalized patients, regardless of whether they had received antimicrobial agents. No bacterial strains resistant to ampicillin, piperacillin, cefoxitin, cefuroxime, imipenem, clindamycin, doxycycline, chloramphenicol, or metronidazole were isolated from the saliva samples. However, resistance to ampicillin, cefoxitin, and cefuroxime was found in strains from 70% of the fecal samples (mainly Bacteroides thetaiotaomicron, Clostridium innocuum, and Bacteroides ovatus). Resistance to both ampicillin and cefuroxime was frequently found in 19% of the isolated strains (mainly B. thetaiotaomicron, B. ovatus, and Bacteroides vulgatus). No strains that were resistant to imipenem, chloramphenicol, or metronidazole were found. Hospitalization and/or intake of antimicrobial agents was associated with an increase in the relative number of resistant anaerobic intestinal bacteria. The percentage of resistant anaerobic strains encountered, compared with the total number of anaerobic bacteria in the normal fecal microflora, was between 5.2 and 14.8%, with the lower value associated with the outpatient group. Two-thirds of the resistant strains from this group had a relative frequency of less than 1% of the total anaerobic flora, while one-third of the strains were present at a level of greater than 1%; for the hospitalized patients, two-thirds of the strains were present at a level of greater than 1%, and one-third of the strains were present at a level of less than 1%. Patients who had received antimicrobial agents for 6 days or more (n = 20) had an average of 1.6 resistant anaerobic strains each, while patients treated for 3 to 5 days (n = 30) had a mean number of 0.87 resistant strains each.
Author C Edlund
C A Stark
G Kristensen
S Sjöstedt
C E Nord
AuthorAffiliation Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
AuthorAffiliation_xml – name: Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
Author_xml – sequence: 1
  givenname: C. A
  surname: STARK
  fullname: STARK, C. A
  organization: Huddinge univ. hosp., Karolinska inst., dep. microbiology, Huddinge, Sweden
– sequence: 2
  givenname: C
  surname: EDLUND
  fullname: EDLUND, C
  organization: Huddinge univ. hosp., Karolinska inst., dep. microbiology, Huddinge, Sweden
– sequence: 3
  givenname: S
  surname: SJÖSTEDT
  fullname: SJÖSTEDT, S
  organization: Huddinge univ. hosp., Karolinska inst., dep. microbiology, Huddinge, Sweden
– sequence: 4
  givenname: G
  surname: KRISTENSEN
  fullname: KRISTENSEN, G
  organization: Huddinge univ. hosp., Karolinska inst., dep. microbiology, Huddinge, Sweden
– sequence: 5
  givenname: C. E
  surname: NORD
  fullname: NORD, C. E
  organization: Huddinge univ. hosp., Karolinska inst., dep. microbiology, Huddinge, Sweden
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4842651$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/8215280$$D View this record in MEDLINE/PubMed
BookMark eNqFkU1r3DAQhkVJSTdpjz0WHCg5BLyRZFkeH3pYlrQpDfSSnsVYlrMKtpxIdkv-fWazy5IeSk_6mOedr_eEHYUxOMY-Cr4UQsLlarVeFtUSlkLr8g1bCF5DrstaH7EF51rnCrh6x05Suuf0Lmt-zI5BilICX7AfqzD5wds4Nh77LLrk04TBusyHbDMPGLIxUgBDSz-TS5MPL090W4nNXrRdT1B6z9522Cf3YX-esl9fr27X1_nNz2_f16ubHEsupxyEUkK5AptCQufoJhvbilZXdYGShuhaVCW0TQtcdqCqptFW8pqLhlsLvDhlX3Z5H-ZmcK11YaIWzUP0A8YnM6I3f0eC35i78bcRQGog_fleH8fHmUYyg0_W9T0GN87JVJpzUFD-FxS6ojXWFYH5DqRdpBRdd2hGcLN1yZBLpqgMmK1LxF_seEyDNPfjHGmp6Z_wp9fjHlLvPaT4530ck8W-i2SfTwdMgZK6FISd7bCNv9v88dEZKm4Q7atSz5K8tPg
CODEN AACHAX
CitedBy_id crossref_primary_10_1590_S0036_46651996000500003
crossref_primary_10_1155_2008_597603
crossref_primary_10_1111_j_1348_0421_2003_tb02781_x
crossref_primary_10_1080_10408398_2017_1379469
crossref_primary_10_1111_j_1572_0241_1999_01016_x
crossref_primary_10_1590_S0102_09351999000600002
crossref_primary_10_1006_anae_1999_0235
crossref_primary_10_1128_AAC_48_1_75_79_2004
crossref_primary_10_1111_j_1365_2885_2007_00910_x
crossref_primary_10_1179_joc_1996_8_1_3
crossref_primary_10_1179_joc_1999_11_5_349
crossref_primary_10_1097_FM9_0000000000000027
crossref_primary_10_1128_AAC_00853_08
crossref_primary_10_1016_S0924_8579_01_00354_5
crossref_primary_10_1179_joc_1996_8_5_331
crossref_primary_10_1006_anae_1999_0183
crossref_primary_10_1006_anae_2000_0341
crossref_primary_10_1016_j_anaerobe_2014_10_004
crossref_primary_10_1111_j_1445_2197_1994_tb02052_x
crossref_primary_10_1128_AAC_47_3_910_916_2003
crossref_primary_10_1111_j_1600_051X_2005_00840_x
crossref_primary_10_1111_j_1365_2885_2008_01033_x
ContentType Journal Article
Copyright 1993 INIST-CNRS
Copyright_xml – notice: 1993 INIST-CNRS
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QL
7T7
8FD
C1K
FR3
P64
7X8
5PM
DOI 10.1128/AAC.37.8.1665
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Bacteriology Abstracts (Microbiology B)
Industrial and Applied Microbiology Abstracts (Microbiology A)
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Engineering Research Database
Technology Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
Bacteriology Abstracts (Microbiology B)
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
MEDLINE - Academic
DatabaseTitleList

CrossRef
MEDLINE

Engineering Research Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Pharmacy, Therapeutics, & Pharmacology
Biology
EISSN 1098-6596
EndPage 1669
ExternalDocumentID 10_1128_AAC_37_8_1665
10.1128/AAC.37.8.1665
8215280
4842651
aac_37_8_1665
Genre Journal Article
Comparative Study
GroupedDBID ---
.55
.GJ
08R
0R~
23M
2WC
39C
3O-
4.4
53G
5GY
5RE
5VS
6J9
AAPBV
AAUGY
ACGFO
ADBBV
AENEX
AFMIJ
AGNAY
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CS3
DIK
E3Z
EBS
EJD
F5P
FRP
GX1
H13
HH5
HYE
HZ~
H~9
IQODW
J5H
K-O
KQ8
L7B
LSO
MVM
NEJ
O9-
OK1
P2P
RHF
RHI
RNS
RPM
RSF
TR2
UHB
VH1
W2D
W8F
WH7
WHG
WOQ
X7M
X7N
XOL
Y6R
ZA5
ZGI
ZXP
~A~
AGVNZ
CGR
CUY
CVF
ECM
EIF
NPM
-
0R
55
A
ABFLS
ADACO
ADBIT
BXI
GJ
HZ
AAYXX
CITATION
7QL
7T7
8FD
C1K
FR3
P64
7X8
5PM
ID FETCH-LOGICAL-a502t-814414e3ab328fe4e32bcd1d6793a2665fda458dbd802f847bb6c20901b0cc803
IEDL.DBID RPM
ISSN 0066-4804
IngestDate Tue Sep 17 20:59:21 EDT 2024
Fri Aug 16 01:27:47 EDT 2024
Fri Aug 16 21:02:49 EDT 2024
Thu Sep 12 17:07:21 EDT 2024
Tue Dec 28 13:58:52 EST 2021
Sat Sep 28 08:38:58 EDT 2024
Sun Oct 29 17:07:05 EDT 2023
Wed May 18 15:37:45 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords Human
Gut
Microflora
Hospitalization
Penicillin derivatives
Resistance
Oral cavity
Antibiotic
Cephalosporin derivatives
Anaerobe
Bacteria
Ambulatory
Feces
Antibacterial agent
Saliva
Comparative study
Language English
License CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a502t-814414e3ab328fe4e32bcd1d6793a2665fda458dbd802f847bb6c20901b0cc803
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
OpenAccessLink https://doi.org/10.1128/aac.37.8.1665
PMID 8215280
PQID 16715297
PQPubID 23462
PageCount 5
ParticipantIDs asm2_journals_10_1128_AAC_37_8_1665
proquest_miscellaneous_16715297
highwire_asm_aac_37_8_1665
crossref_primary_10_1128_AAC_37_8_1665
pascalfrancis_primary_4842651
pubmedcentral_primary_oai_pubmedcentral_nih_gov_188038
pubmed_primary_8215280
proquest_miscellaneous_76008485
PublicationCentury 1900
PublicationDate 1993-08-01
PublicationDateYYYYMMDD 1993-08-01
PublicationDate_xml – month: 08
  year: 1993
  text: 1993-08-01
  day: 01
PublicationDecade 1990
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
PublicationTitle Antimicrobial Agents and Chemotherapy
PublicationTitleAlternate Antimicrob Agents Chemother
PublicationYear 1993
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
SSID ssj0006590
Score 1.6026074
Snippet Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
In the present study we determined the resistance patterns of anaerobic bacteria from human saliva and stool specimens and investigated whether there were...
SourceID pubmedcentral
proquest
crossref
asm2
pubmed
pascalfrancis
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 1665
SubjectTerms Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Antineoplastic agents
Bacteria, Anaerobic
Bacteria, Anaerobic - drug effects
Bacteroides fragilis - drug effects
Biological and medical sciences
Chemotherapy
Drug Resistance, Microbial
Feces - microbiology
Female
Humans
Intestines
Intestines - microbiology
Length of Stay
Male
Medical sciences
Middle Aged
Mouth
Mouth - microbiology
Pharmacology. Drug treatments
Research Article
Saliva - microbiology
Title Antimicrobial resistance in human oral and intestinal anaerobic microfloras
URI http://aac.asm.org/content/37/8/1665.abstract
https://www.ncbi.nlm.nih.gov/pubmed/8215280
https://journals.asm.org/doi/10.1128/AAC.37.8.1665
https://search.proquest.com/docview/16715297
https://search.proquest.com/docview/76008485
https://pubmed.ncbi.nlm.nih.gov/PMC188038
Volume 37
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED_WQEdfRpetLF27CTbyVDu2LMnKYwgrZSMjDy30TejLLNCoZU4f8t_v5I-0GevL3mwknWXfne8k3f0O4OsUZ-ccz5KIXZWwKmeJtE5HGFfnuc5tJmPu8OKnuLph32_5bZcUVndhlcGaVRru1mlY_WpiKx_WdtLHiU2Wi3nEECvk5AAOyqLoV-jd31fwdl8FTWnCZMZ6XE0qJ7PZPC3KVKa5EPwIDmWs6RrxIAe6XtN9w9SDBcdYSV3j56raOhf_ckT_jqd8ZqAuj-FN51mSWfsGb-GVD0M4bGtNbofwetGdog9hvGzxqrcX5Pop_aq-IGOyfEKy3r6DH7OwWa1XDVYTksaVefQ2UUzIKpCmuh-JCf5EB0ci7gT-LkJzq30cYkkztrrDTvV7uLn8dj2_SrrqC4nmGd3EvUGWM19oU1BZebyixrrcCdRojWadV04zLp1xMqMVGjljhKUZ-hcmsxYZdAKDcB_8ByCOM-8rUWhtBJvaUjoh6NRkeaVlWRk6gi-RA6pTn1o1KxMqFXJMFaWSKnJsBOOeQeqhheJ4qeNpzz6FdJXW9nnj-R5Dd6SYRGeF5yP43DNYoabF4xMd_P0jTkqUKC_T8uUe8ZBTMonPOGkFYke8E7URiD1J2bVHkO_9FpT9Buy7lfXT_x34EY7aEM0YsngGg83vR3-ObtTGfGr05g-0Mxv5
link.rule.ids 230,315,733,786,790,891,27955,27956,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLegaLALH4VpHYxZAvW0pIljO-6xqpgKW6ceWmk3yx-JiFi9aWkP5a_nOR_dOrED3BI927Hjn_2e7effQ-jrEGpnLYsCz10V0DymgTBWeRpXmzEVm0j4u8PTSz5Z0B9X7Kq5FFY2bpXO6CJ018vQFT8r38rbpRm0fmKD2XTsOcQSMXiOXsBwJaxdozfzL2f1zgoo04CKiLbMmkQMRqNxmKShCGPO2T7aEz6qq2eE7KhySXZVU0sX7L0lVQk_LK8jXfzNFH3sUflARZ29QYu2cbVnyq9wvdKh-f2I9_FfW_8WvW5sVjyqpe_Qs8x10V4dxXLTRS-nzfl8F_VnNRP25hTP7y92lae4j2f3HNmb9-h85FbFsqhYoKBoWPN7OxYAiAuHq7iB2FMHYOUs9owWMBG56lVlPovBVd78GhKVH9Di7Nt8PAmauA6BYhFZ-V1HGtMsUTohIs_giWhjY8thrlBgMLDcKsqE1VZEJAf1qTU3JALLRUfGQOMPUMfduOwQYctoluU8UUpzOjSpsJyToY7iXIk016SHvvielc3ALGW15iFCAhJkkkohPRJ6qN92vLytST6eSnjUwkJCuVIp81B4vAOUbVFUgBnE4h46aYEjYQz7gxnlsps1VIqngMNh-nQKf3wqqIBvHNRA2xbeQLiH-A4Ct3JPH74rAVxVNOI1jo7-N-MJejWZTy_kxffL849ov3YE9Y6Rn1BndbfOjsFYW-nP1dj8A2caPbo
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFH8aRZt2GVCY6GDMEqinJU0cx3GPVaEajE49bNI4Wf5IRMWaVSQ9dH89z_no1olddktk-8Wxf_Z7tp9_D-DLEGtnbRx4jrvKY1nIPGGscjSuNo1VaALh7g5PL_jZFftxHV_vgGjvwlRO-0bP_fxm4efz35Vv5XJhBq2f2GA2HTsOsUgMljYbvICXOGRp0q7TmzmYx_XuCipUj4mAteyaVAxGo7EfJb7wQ87jfdgVLrKrY4XsqGJBt9VTSxnsPCZVgY2W1dEu_meOPvaqfKCmJq_gV_uDtXfKH39Vat_cPeJ-fE4LvIaDxnYlozrHG9hJ8y7s1tEs113Ymzbn9F3oz2pG7PUpuby_4FWckj6Z3XNlr9_C-Sgv54t5xQaFonHt7-xZBCKZ56SKH0gchQBRuSWO2QInpLx6VakrYkhVNrvBTMU7uJp8uxyfeU18B0_FAS3d7iMLWRopHVGRpfhEtbGh5ThnKDQc4swqFgurrQhohmpUa25ogBaMDozBBjiETn6bp--B2JilacYjpTRnQ5MIyzkd6iDMlEgyTXvw2fWubAZoIau1DxUS0SCjRArp0NCDftv5clmTfTyV8aiFhkS5UinzMPF4CywbUUygORSHPThpwSNxLLsDGpWntyusFE8Qi8Pk6RzuGFUwgd84rMG2Ed7AuAd8C4WbdEcjvp2C2KroxGssHT234Anszb5O5M_vF-cfYL_2B3X-kR-hU_5dpcdos5X6UzU8_wFM7kA6
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Antimicrobial+resistance+in+human+oral+and+intestinal+anaerobic+microfloras&rft.jtitle=Antimicrobial+Agents+and+Chemotherapy&rft.au=C+A+Stark&rft.au=C+Edlund&rft.au=S+Sj%C3%B6stedt&rft.au=G+Kristensen&rft.date=1993-08-01&rft.pub=American+Society+for+Microbiology&rft.issn=0066-4804&rft.eissn=1098-6596&rft.volume=37&rft.issue=8&rft.spage=1665&rft_id=info:doi/10.1128%2FAAC.37.8.1665&rft_id=info%3Apmid%2F8215280&rft.externalDBID=n%2Fa&rft.externalDocID=aac_37_8_1665
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0066-4804&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0066-4804&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0066-4804&client=summon